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Thalamocortical Mechanisms for Nostalgia-Induced Analgesia

文献类型：期刊论文

作者Zhang, Ming3,4; Yang, Ziyan3,4; Zhong, Jiahui2; Zhang, Yuqi3,4; Lin, Xiaomin4; Cai, Huajian3,4; Kong, Yazhuo1,3,4
刊名JOURNAL OF NEUROSCIENCE
出版日期2022-04-06
卷号42期号:14页码:2963-2972
关键词analgesia nostalgia PAG pain thalamus
ISSN号0270-6474
DOI10.1523/JNEUROSCI.2123-21.2022
通讯作者Cai, Huajian(caihj@psych.ac.cn) ; Kong, Yazhuo(kongyz@psych.ac.cn)
英文摘要As a predominately positive emotion, nostalgia serves various adaptive functions, including a recently revealed analgesic effect. The current fMRI study aimed to explore the neural mechanisms underlying the nostalgia-induced analgesic effect on noxious thermal stimuli of different intensities. Human participants' (males and females) behavior results showed that the nostalgia paradigm significantly reduced participants' perception of pain, particularly at low pain intensities. fMRI analysis revealed that analgesia was related to decreased brain activity in pain-related brain regions, including the lingual and parahippocampal gyrus. Notably, anterior thalamic activation during the nostalgia stage predicted posterior parietal thalamus activation during the pain stage, suggesting that the thalamus might play a key role as a central functional linkage in the analgesic effect. Moreover, while thalamus-PAG functional connectivity was found to be related to nostalgic strength, periaqueductal gray-dorsolateral prefrontal cortex (PAG-dlPFC) functional connectivity was found to be associated with pain perception, suggesting possible analgesic modulatory pathways. These findings demonstrate the analgesic effect of nostalgia and, more importantly, shed light on its neural mechanism.
收录类别SCI
WOS关键词PAIN RELIEF ; MEMORY ; ROBUST ; FMRI ; MUSIC ; OPTIMIZATION ; REGISTRATION ; MODULATION ; RESPONSES ; EMOTIONS
资助项目National Natural Science Foundation of China[32100861] ; National Natural Science Foundation of China[81871436] ; National Natural Science Foundation of China[82072010] ; National Natural Science Foundation of China[82030121] ; National Natural Science Foundation of China[32000775] ; National Social Science Fund of China[17ZDA324] ; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences (CAS)
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000784244200012
出版者SOC NEUROSCIENCE
资助机构National Natural Science Foundation of China ; National Social Science Fund of China ; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences (CAS)
源URL[http://ir.psych.ac.cn/handle/311026/42484]  
专题心理研究所_中国科学院行为科学重点实验室
中国科学院心理研究所
通讯作者Cai, Huajian; Kong, Yazhuo
作者单位1.Univ Oxford, Nuffield Dept Clin Neurosci, FMRIB, Wellcome Ctr Integrat Neuroimaging, Oxford OX3 9DU, England
2.Liaoning Normal Univ, Res Ctr Brain & Cognit Neurosci, Dalian 116029, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ming,Yang, Ziyan,Zhong, Jiahui,et al. Thalamocortical Mechanisms for Nostalgia-Induced Analgesia[J]. JOURNAL OF NEUROSCIENCE,2022,42(14):2963-2972.
APA Zhang, Ming.,Yang, Ziyan.,Zhong, Jiahui.,Zhang, Yuqi.,Lin, Xiaomin.,...&Kong, Yazhuo.(2022).Thalamocortical Mechanisms for Nostalgia-Induced Analgesia.JOURNAL OF NEUROSCIENCE,42(14),2963-2972.
MLA Zhang, Ming,et al."Thalamocortical Mechanisms for Nostalgia-Induced Analgesia".JOURNAL OF NEUROSCIENCE 42.14(2022):2963-2972.

入库方式： OAI收割

来源：心理研究所

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