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p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing

文献类型：期刊论文

作者Li, Jin3,7; Cao, Dan3,7; Dimakopoulos, Vasileios8; Shi, Weiyang3,6,7; Yu, Shan2,3,6,7; Fan, Lingzhong2,3,6,7; Stieglitz, Lennart8; Imbach, Lukas1; Sarnthein, Johannes4,8; Jiang, Tianzi2,3,5,6,7
刊名JOURNAL OF NEUROSCIENCE
出版日期2022-01-19
卷号42期号:3页码:443-453
关键词hippocampus intracranial EEG longitudinal axis working memory
ISSN号0270-6474
DOI10.1523/JNEUROSCI.1287-21.2021
通讯作者Sarnthein, Johannes(johannes.samthein@usz.ch) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要The hippocampus is a locus of working memory (WM) with anterior and posterior subregions that differ in their transcriptional and external connectivity patterns. However, the involvement and functional connections between these subregions in WM processing are poorly understood. To address these issues, we recorded intracranial EEG from the anterior and the posterior hippocampi in humans (seven females and seven males) who maintained a set of letters in their WM. We found that WM maintenance was accompanied by elevated low-frequency activity in both the anterior and posterior hippocampus and by increased theta/alpha band (3-12 Hz) phase synchronization between anterior and posterior subregions. Cross-frequency and Granger prediction analyses consistently showed that the correct WM trials were associated with theta/alpha band-coordinated unidirectional influence from the posterior to the anterior hippocampus. In contrast, WM errors were associated with bidirectional interactions between the anterior and posterior hippocampus. These findings imply that theta/alpha band synchrony within the hippocampus may support successful WM via a posterior to anterior influence. A combination of intracranial recording and a fine-grained atlas may be of value in understanding the neural mechanisms of WM processing.
WOS关键词PERSISTENTLY ACTIVE NEURONS ; THETA-OSCILLATIONS ; VENTRAL HIPPOCAMPUS ; LONG-AXIS ; ORGANIZATION ; DORSAL ; DISSOCIATION ; TOOLBOX ; GAMMA ; RAT
资助项目National Key Research and Development Program of China[2017YFA0105203] ; Chinese Academy of Sciences Science and Technology Service Network Initiative[KFJ-STSZDTP-078] ; National Natural Science Foundation of China[31300934] ; National Natural Science Foundation of China[31620103905] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; National Key R&D Program of China[2017YFA0105203] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[CNLYB2004] ; CAS Key Laboratory of Behavioral Science ; Swiss National Science Foundation[SNSF 176222] ; Institute of Psychology
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000746045100002
出版者SOC NEUROSCIENCE
资助机构National Key Research and Development Program of China ; Chinese Academy of Sciences Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; CAS Key Laboratory of Behavioral Science ; Swiss National Science Foundation ; Institute of Psychology
源URL[http://ir.ia.ac.cn/handle/173211/47253]  
专题中国科学院自动化研究所
通讯作者Sarnthein, Johannes; Jiang, Tianzi
作者单位1.Swiss Epilepsy Ctr, CH-8008 Zurich, Switzerland
2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
4.Swiss Fed Inst Technol, Zurich Neurosci Ctr, CH-8057 Zurich, Switzerland
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
6.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
8.Univ Zurich, Univ Hosp Zurich, Dept Neurosurg, CH-8091 Zurich, Switzerland
推荐引用方式
GB/T 7714		 Li, Jin,Cao, Dan,Dimakopoulos, Vasileios,et al. p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing[J]. JOURNAL OF NEUROSCIENCE,2022,42(3):443-453.
APA Li, Jin.,Cao, Dan.,Dimakopoulos, Vasileios.,Shi, Weiyang.,Yu, Shan.,...&Jiang, Tianzi.(2022).p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing.JOURNAL OF NEUROSCIENCE,42(3),443-453.
MLA Li, Jin,et al."p Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing".JOURNAL OF NEUROSCIENCE 42.3(2022):443-453.

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来源：自动化研究所

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