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In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy

文献类型：期刊论文

作者Zhang, Lu2,3,4; Ding, Yunhe2,3,4; Chen, Xinjian1,5; Xiang, Dehui1,5; Shi, Fei1,5; Chen, Yanyun7; Yan, Shenshen7; Zhang, Xinyuan7; Tian, Jie3; Siva Prasad, Sobha6
刊名BIOMEDICAL OPTICS EXPRESS
出版日期2021-11-01
卷号12期号:11页码:7185-7198
ISSN号2156-7085
DOI10.1364/BOE.439446
通讯作者Du, Yang(yang.du@ia.ac.cn)
英文摘要Anti-vascular endothelial growth factor (anti-VEGF) therapy is effective for reducing the severity level of diabetic retinopathy (DR). However, it is difficult to determine the in vivo spatial and temporal expression of VEGF in the DR retina at an early stage. Here, we report a quantitatively fluorescence molecular imaging and image analysis method by creating a VEGF targeted fluorescence imaging probe, which can potentially detect and predict anti-VEGF treatment response. Moreover, the ex vivo multiscale fluorescence imaging demonstrated the spatial correlation between VEGF relative expression and vascular abnormalities in two and three dimensions. It revealed that VEGF was mainly abnormally expressed at the bifurcation of the microvessels, which advances the knowledge of the DR progression by molecular fluorescence imaging. Our study has the potential to achieve early detection of DR disease, provide more insight into understanding anti-VEGF treatment, and may help stratify patients based on the molecular imaging of retinal VEGF.
WOS关键词MAJOR RISK-FACTORS ; GLOBAL PREVALENCE ; VEGF ; NEUTRALIZATION ; RANIBIZUMAB ; BEVACIZUMAB ; AFLIBERCEPT ; PROGRESSION
资助项目National Natural Science Foundation of China[61771326] ; National Natural Science Foundation of China[61827809] ; Science and Technology Project of Beijing Municipal Commission of Education[KM202010025026]
WOS研究方向Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者OPTICAL SOC AMER
WOS记录号WOS:000717641100003
资助机构National Natural Science Foundation of China ; Science and Technology Project of Beijing Municipal Commission of Education
源URL[http://ir.ia.ac.cn/handle/173211/46515]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Du, Yang
作者单位1.Soochow Univ, State Key Lab Radiat Med & Protect, Suzhou 215006, Jiangsu, Peoples R China
2.Capital Med Univ, Beijing Key Lab Fundamental Res Biomech Clin Appl, Beijing 100069, Peoples R China
3.Inst Automat, Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China
5.Soochow Univ, Sch Elect & Informat Engn, Suzhou 215006, Jiangsu, Peoples R China
6.Moorfields Eye Hosp, NIHR Moorfields Biomed Res Ctr, London EC1V 2PD, England
7.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Lu,Ding, Yunhe,Chen, Xinjian,et al. In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy[J]. BIOMEDICAL OPTICS EXPRESS,2021,12(11):7185-7198.
APA Zhang, Lu.,Ding, Yunhe.,Chen, Xinjian.,Xiang, Dehui.,Shi, Fei.,...&Tian, Bei.(2021).In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy.BIOMEDICAL OPTICS EXPRESS,12(11),7185-7198.
MLA Zhang, Lu,et al."In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy".BIOMEDICAL OPTICS EXPRESS 12.11(2021):7185-7198.

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来源：自动化研究所

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