Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer
文献类型：期刊论文
| 作者 | Liu,Yu1,2,3,4 ; Shang,Wenting3; Liu,Heng6; Hui,Hui3; Wu,Jun3; Zhang,Wei3; Gao,Pengli1,2,3; Guo,Kunxiong3; Guo,Yanli4; Tian,Jie1,2,3,5
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| 刊名 | Journal of Nanobiotechnology
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| 出版日期 | 2022-01-24 |
| 卷号 | 20期号:1 |
| 关键词 | Tumor-associated macrophages Immunomodulation Hyperthermia-immunotherapy Eumelanin Prostate cancer |
| DOI | 10.1186/s12951-022-01248-5 |
| 通讯作者 | Guo,Yanli(guoyanli71@aliyun.com) ; Tian,Jie(jie.tian@ia.ac.cn) |
| 英文摘要 | AbstractPro-tumoral and immunosuppressive M2-like tumor-associated macrophages (TAMs) contribute to tumor progression, recurrence and distal metastasis. However, current TAMs-modulating therapeutic strategies often encounter challenges including insufficient immune activation, weak antigen presentation ability and unsatisfactory antitumor immune performance. Herein, cyclic RGD peptide functionalized and manganese doped eumelanin-like nanocomposites (RMnMels) are reported for combined hyperthermia-immunotherapy against PC3 prostate cancer. The RMnMels could promote M2-to-M1 macrophage repolarization via scavenging multiple reactive oxygen species and remodeling the immunosuppressive tumor microenvironment. Following near-infrared light irradiation, RMnMels-mediated thermal ablation not only could destroy tumor cells directly, but also elicit the release of damage associated molecular patterns and tumor-associated antigens, provoking robust tumor immunogenicity and strong antitumor immune responses. The results showed that RMnMels could effectively scavenge reactive oxygen species and promote M2-to-M1 macrophage repolarization both in vitro and in vivo. Synergistically enhanced anti-tumor therapeutic efficacy was achieved following single administration of RMnMels plus single round of laser irradiation, evidenced by decreased primary tumor sizes and decreased number of distant liver metastatic nodules. The as-developed RMnMels may represent a simple and high-performance therapeutic nanoplatform for immunomodulation and enhanced antitumor immune responses.Graphical Abstract |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12951-022-01248-5 |
| 出版者 | BioMed Central |
| 源URL | [http://ir.ia.ac.cn/handle/173211/47197]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Guo,Yanli; Tian,Jie |
| 作者单位 | 1.Beihang University, Ministry of Industry and Information Technology; Key Laboratory of Big Data-Based Precision Medicine 2.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering 3.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation 4.Army Medical University; Department of Ultrasound, Southwest Hospital 5.Xidian University; Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology 6.PLA Rocket Force Characteristic Medical Center; Department of Radiology |
| 推荐引用方式 GB/T 7714 | Liu,Yu,Shang,Wenting,Liu,Heng,et al. Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer[J]. Journal of Nanobiotechnology,2022,20(1). |
| APA | Liu,Yu.,Shang,Wenting.,Liu,Heng.,Hui,Hui.,Wu,Jun.,...&Tian,Jie.(2022).Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer.Journal of Nanobiotechnology,20(1). |
| MLA | Liu,Yu,et al."Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer".Journal of Nanobiotechnology 20.1(2022). |
入库方式： OAI收割
来源：自动化研究所
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