Characterization of metabolic landscape in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Wu, Jing1; Xue, Ran3; Jiang, Rong-Tao2 ; Meng, Qing-Hua1
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| 刊名 | WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
 |
| 出版日期 | 2021-09-15 |
| 卷号 | 13期号:9页码:1144-1156 |
| 关键词 | Hepatocellular carcinoma Metabolic reprogramming Glycolysis Lipid metabolism Glutamine addiction Diagnosis and treatment |
| ISSN号 | 1948-5204 |
| DOI | 10.4251/wjgo.v13.i9.1144 |
| 通讯作者 | Meng, Qing-Hua(meng_qh0805@ccmu.edu.cn) |
| 英文摘要 | Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, accounting for approximately 75%-85% of primary liver cancers. Metabolic alterations have been labeled as an emerging hallmark of tumors. Specially, the last decades have registered a significant improvement in our understanding of the role of metabolism in driving the carcinogenesis and progression of HCC. In this paper, we provide a review of recent studies that investigated the metabolic traits of HCC with a specific focus on three common metabolic alterations involving glycolysis, lipid metabolism, and glutamine addiction which have been gaining much attention in the field of HCC. Next, we describe some representative diagnostic markers or tools, and promising treatment agents that are proposed on the basis of the aforementioned metabolic alterations for HCC. Finally, we present some challenges and directions that may promisingly speed up the process of developing objective diagnostic markers and therapeutic options underlying HCC. Specifically, we recommend future investigations to carefully take into account the influence of heterogeneity, control for study-specific confounds, and invite the validation of existing biomarkers. |
| WOS关键词 | LIVER-CANCER ; THERAPEUTIC TARGET ; GLUCOSE-METABOLISM ; ACID ; SORAFENIB ; GROWTH ; CELLS ; RESISTANCE ; EXPRESSION ; BIOMARKERS |
| 资助项目 | Municipal Natural Science Foundation of Beijing, China[7192085] ; National Science and Technology Major Project of China[2018ZX10302206-003-007] ; National Science and Technology Major Project of China[2017ZX10203202-001-005] ; Capital Health Research and Development of Special[20181-3011] ; National Natural Science Foundation of China[81470877] |
| WOS研究方向 | Oncology ; Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000736478800013 |
| 出版者 | BAISHIDENG PUBLISHING GROUP INC |
| 资助机构 | Municipal Natural Science Foundation of Beijing, China ; National Science and Technology Major Project of China ; Capital Health Research and Development of Special ; National Natural Science Foundation of China |
| 源URL | [http://ir.ia.ac.cn/handle/173211/47133]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Meng, Qing-Hua |
| 作者单位 | 1.Capital Med Univ, Beijing You An Hosp, Dept Med Oncol, 8 Xi Tou Tiao, Beijing 100069, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100036, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jing,Xue, Ran,Jiang, Rong-Tao,et al. Characterization of metabolic landscape in hepatocellular carcinoma[J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY,2021,13(9):1144-1156. |
| APA | Wu, Jing,Xue, Ran,Jiang, Rong-Tao,&Meng, Qing-Hua.(2021).Characterization of metabolic landscape in hepatocellular carcinoma.WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY,13(9),1144-1156. |
| MLA | Wu, Jing,et al."Characterization of metabolic landscape in hepatocellular carcinoma".WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 13.9(2021):1144-1156. |
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来源：自动化研究所
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