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Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice

文献类型：期刊论文

作者Zhou, Xiaoqing Alice3; Blackmore, Daniel G.3; Zhuo, Junjie1,3; Nasrallah, Fatima A.2,3; To, XuanVinh3; Kurniawan, Nyoman D.2; Carlisle, Alison3; Vien, King-Year3; Chuang, Kai-Hsiang2,3; Jiang, Tianzi1,3
刊名ISCIENCE
出版日期2021-12-17
卷号24期号:12页码:20
DOI10.1016/j.isci.2021.103450
通讯作者Chuang, Kai-Hsiang(k.chuang@uq.edu.au) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Bartlett, Perry F.(p.bartlett@uq.edu.au)
英文摘要We have shown that the improvement in hippocampal-based learning in aged mice following physical exercise observed is dependent on neurogenesis in the dentate gyrus (DG) and is regulated by changes in growth hormone levels. The changes in neurocircuitry, however, which may underlie this improvement, remain unclear. Using in vivo multimodal magnetic resonance imaging to track changes in aged mice exposed to exercise, we show the improved spatial learning is due to enhanced DG connectivity, particularly the strengthening of the DG-Cornu Ammonis 3 and the DG-medial entorhinal cortex connections in the dorsal hippocampus. Moreover, we provide evidence that these changes in circuitry are dependent on neurogenesis since they were abrogated by ablation of newborn neurons following exercise. These findings identify the specific changes in hippocampal circuitry that underlie the cognitive improvements resulting from physical activity and show that they are dependent on the activation of neurogenesis in aged animals.
WOS关键词ACTIVE PLACE AVOIDANCE ; FUNCTIONAL CONNECTIVITY ; VENTRAL HIPPOCAMPUS ; PATTERN SEPARATION ; DENTATE GYRUS ; MEMORY ; DORSAL ; VOLUME ; CELLS ; PROLIFERATION
资助项目National Health and Medical Research Council[GNT1130141] ; Stafford Fox Medical Research Foundation
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000740254100001
出版者CELL PRESS
资助机构National Health and Medical Research Council ; Stafford Fox Medical Research Foundation
源URL[http://ir.ia.ac.cn/handle/173211/47169]  
专题自动化研究所_脑网络组研究中心
通讯作者Chuang, Kai-Hsiang; Jiang, Tianzi; Bartlett, Perry F.
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
2.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia
3.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式
GB/T 7714		 Zhou, Xiaoqing Alice,Blackmore, Daniel G.,Zhuo, Junjie,et al. Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice[J]. ISCIENCE,2021,24(12):20.
APA Zhou, Xiaoqing Alice.,Blackmore, Daniel G..,Zhuo, Junjie.,Nasrallah, Fatima A..,To, XuanVinh.,...&Bartlett, Perry F..(2021).Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice.ISCIENCE,24(12),20.
MLA Zhou, Xiaoqing Alice,et al."Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice".ISCIENCE 24.12(2021):20.

入库方式： OAI收割

来源：自动化研究所

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