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Continuous theta-burst stimulation modulates resting-state EEG microstates in healthy subjects

文献类型：期刊论文

作者Qiu, Shuang3,4; Wang, Shengpei3; Peng, Weiwei5; Yi, Weibo6; Zhang, Chuncheng3; Zhang, Jing1; He, Huiguang2,3,4
刊名COGNITIVE NEURODYNAMICS
出版日期2021-10-16
页码11
ISSN号1871-4080
关键词Continuous theta-burst stimulation Resting-state EEG Brain dynamics EEG microstate Microstate functional connectivity
DOI10.1007/s11571-021-09726-6
通讯作者Qiu, Shuang(shuang.qiu@ia.ac.cn) ; He, Huiguang(huiguang.he@ia.ac.cn)
英文摘要Continuous theta-burst stimulation (cTBS) induces long-lasting inhibitory effects on cortical excitability. Although cTBS has been reported to modulate neural oscillations and functional connectivity, it is still unclear how cTBS affects brain dynamics that could be captured by the resting-sate EEG microstate sequences. This study aims to investigate how cTBS over the left motor cortex affects brain dynamics. We applied 40 s-long cTBS over the left motor cortex of 28 healthy participants. Before and in multi-sessions up to 90 min after cTBS, their performance in a Nine-Hole Peg Test (NHPT), that measures the hand dexterity, and resting state EEG were recorded. Resting-sate EEG data were clustered into four microstates (namely A, B, C, and D) using k-means clustering algorithms. cTBS-induced changes in NHPT performance, microstate dynamics and functional connectivity networks were comprehensively assessed. As compared with baseline, the completion time of NHPT became shorter immediately after cTBS, suggesting cTBS-induced motor function improvement. After cTBS, the topography of microstate B revealed a greater change compared with other three topographies. Importantly, cTBS-induced decrease in completion time of NHPT correlated with cTBS-induced decrease of the mean occurrence of microstate B. Functional connectivity analysis further revealed that cTBS led to an increase of the node efficiency at C4 electrode in microstate B. These results indicated the specific modulation of cTBS over the motor cortex on the dynamics of microstate B. This work provided the evidence of the association between B and motor function, and it also implies the modulation of cTBS over the motor network.
WOS关键词TRANSCRANIAL MAGNETIC STIMULATION ; LOW-FREQUENCY RTMS ; CORTEX ; CONNECTIVITY ; TOPOGRAPHY ; BRAIN ; TMS ; SCHIZOPHRENIA ; STROKE ; PHASE
资助项目National Natural Science Foundation of China[81701785] ; National Natural Science Foundation of China[62006014] ; National Natural Science Foundation of China[62020106015] ; National Natural Science Foundation of China[61976209] ; National Natural Science Foundation of China[61906188] ; Strategic Priority Research Program of CAS[XDB32040200] ; CAS International Collaboration Key Project[173211KYSB20190024] ; Beijing Municipal Natural Science Foundation[4214078]
WOS研究方向Neurosciences & Neurology
语种英语
出版者SPRINGER
WOS记录号WOS:000707528800001
资助机构National Natural Science Foundation of China ; Strategic Priority Research Program of CAS ; CAS International Collaboration Key Project ; Beijing Municipal Natural Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/46236]  
专题类脑智能研究中心_神经计算及脑机交互
通讯作者Qiu, Shuang; He, Huiguang
作者单位1.Capital Med Univ, Beijing Tiantan Hosp, Rehabil Dept, Beijing, Peoples R China
2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
3.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Shenzhen Univ, Sch Psychol, Shenzhen, Peoples R China
6.Beijing Machine & Equipment Inst, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Qiu, Shuang,Wang, Shengpei,Peng, Weiwei,et al. Continuous theta-burst stimulation modulates resting-state EEG microstates in healthy subjects[J]. COGNITIVE NEURODYNAMICS,2021:11.
APA Qiu, Shuang.,Wang, Shengpei.,Peng, Weiwei.,Yi, Weibo.,Zhang, Chuncheng.,...&He, Huiguang.(2021).Continuous theta-burst stimulation modulates resting-state EEG microstates in healthy subjects.COGNITIVE NEURODYNAMICS,11.
MLA Qiu, Shuang,et al."Continuous theta-burst stimulation modulates resting-state EEG microstates in healthy subjects".COGNITIVE NEURODYNAMICS (2021):11.

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来源：自动化研究所

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