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Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells

文献类型：期刊论文

作者Liu, Jing7,8,9; Wang, Shengxiong1,4; Lu, Yan1,2,5,6; Wang, Haoyu1,2,5,6; Wang, Fangfang1; Qiu, Miaoxin4; Xie, Qiwei3; Han, Hua7,8,9; Hua, Yunfeng1,2,5,6
刊名NEUROSCIENCE BULLETIN
出版日期2021-11-27
页码14
ISSN号1673-7067
关键词Inner hair cell Ribbon synapse Mitochondrial network Volume electron microscopy AI-based image processing
DOI10.1007/s12264-021-00801-w
通讯作者Han, Hua(hua.han@ia.ac.cn) ; Hua, Yunfeng(yunfeng.hua@shsmu.edu.cn)
英文摘要Recent studies have revealed great functional and structural heterogeneity in the ribbon-type synapses at the basolateral pole of the isopotential inner hair cell (IHC). This feature is believed to be critical for audition over a wide dynamic range, but whether the spatial gradient of ribbon morphology is fine-tuned in each IHC and how the mitochondrial network is organized to meet local energy demands of synaptic transmission remain unclear. By means of three-dimensional electron microscopy and artificial intelligence-based algorithms, we demonstrated the cell-wide structural quantification of ribbons and mitochondria in mature mid-cochlear IHCs of mice. We found that adjacent IHCs in staggered pairs differ substantially in cell body shape and ribbon morphology gradient as well as mitochondrial organization. Moreover, our analysis argues for a location-specific arrangement of correlated ribbon and mitochondrial function at the basolateral IHC pole.
WOS关键词QUANTITATIVE-ANALYSIS ; RESPONSE PROPERTIES ; NERVE FIBERS ; CAT COCHLEA ; AFFERENT ; RECONSTRUCTION ; HETEROGENEITY ; INNERVATION ; GRADIENTS ; VESICLES
资助项目National Natural Science Foundation of China[81800901] ; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning[QD2018015] ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases[14DZ2260300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030200] ; Bureau of International Cooperation, Chinese Academy of Sciences[153D31KYSB20170059]
WOS研究方向Neurosciences & Neurology
语种英语
出版者SPRINGER
WOS记录号WOS:000722958700001
资助机构National Natural Science Foundation of China ; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Bureau of International Cooperation, Chinese Academy of Sciences
源URL[http://ir.ia.ac.cn/handle/173211/46548]  
专题类脑智能研究中心_微观重建与智能分析
通讯作者Han, Hua; Hua, Yunfeng
作者单位1.Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Inst Precis Med, Sch Med, Shanghai 200125, Peoples R China
2.Shanghai Key Lab Translat Med Ear & Nose Dis, Shanghai 200125, Peoples R China
3.Beijing Univ Technol, Res Base Beijing Modern Mfg Dev, Beijing 100124, Peoples R China
4.Tongji Univ, Putuo Peoples Hosp, Shanghai 200060, Peoples R China
5.Shanghai Jiao Tong Univ, Ear Inst, Sch Med, Shanghai 200125, Peoples R China
6.Shanghai Ninth Peoples Hosp, Dept OtolaryngologyHead & Neck Surg, Shanghai 200125, Peoples R China
7.CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
8.Univ Chinese Acad Sci, Sch Artificial Intelligence, Sch Future Technol, Beijing 101408, Peoples R China
9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Jing,Wang, Shengxiong,Lu, Yan,et al. Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells[J]. NEUROSCIENCE BULLETIN,2021:14.
APA Liu, Jing.,Wang, Shengxiong.,Lu, Yan.,Wang, Haoyu.,Wang, Fangfang.,...&Hua, Yunfeng.(2021).Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells.NEUROSCIENCE BULLETIN,14.
MLA Liu, Jing,et al."Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells".NEUROSCIENCE BULLETIN (2021):14.

入库方式： OAI收割

来源：自动化研究所

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