Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor
文献类型:期刊论文
作者 | Qu,Qiaojun8,9; Zhang,Zeyu7,8![]() ![]() ![]() ![]() ![]() |
刊名 | Journal of Nanobiotechnology
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出版日期 | 2022-03-19 |
卷号 | 20期号:1 |
关键词 | Aggregation-induced emission NIR-II imaging Phototherapy Phototheranostic Residual tumor |
DOI | 10.1186/s12951-022-01325-9 |
通讯作者 | Zhang,Hui(zhang_hui@sxmu.edu.cn) ; Xu,Pengfei(pengfeixuscu@outlook.com) ; Hu,Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian,Jie(jie.tian@ia.ac.cn) |
英文摘要 | AbstractIncomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1–π–A–D2–R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2?mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes.Graphic Abstract |
语种 | 英语 |
WOS记录号 | BMC:10.1186/S12951-022-01325-9 |
出版者 | BioMed Central |
源URL | [http://ir.ia.ac.cn/handle/173211/47642] ![]() |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
通讯作者 | Zhang,Hui; Xu,Pengfei; Hu,Zhenhua; Tian,Jie |
作者单位 | 1.Jining Medical University; Institute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital 2.First Hospital of Shanxi Medical University; Department of Radiology 3.University of Chinese Academy of Sciences; School of Artificial Intelligence 4.Southern Medical University; Department of Hepatobiliary Surgery, Zhujiang Hospital 5.Anhui Medical University 6.Chinese PLA General Hospital; Department of Gastroenterology, The Third Medical Centre 7.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering 8.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation 9.Shanxi Medical University; College of Medical Imaging |
推荐引用方式 GB/T 7714 | Qu,Qiaojun,Zhang,Zeyu,Guo,Xiaoyong,et al. Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor[J]. Journal of Nanobiotechnology,2022,20(1). |
APA | Qu,Qiaojun.,Zhang,Zeyu.,Guo,Xiaoyong.,Yang,Junying.,Cao,Caiguang.,...&Tian,Jie.(2022).Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor.Journal of Nanobiotechnology,20(1). |
MLA | Qu,Qiaojun,et al."Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor".Journal of Nanobiotechnology 20.1(2022). |
入库方式: OAI收割
来源:自动化研究所
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