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Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor

文献类型：期刊论文

作者Qu,Qiaojun8,9; Zhang,Zeyu7,8; Guo,Xiaoyong5,6,8; Yang,Junying4; Cao,Caiguang3,8; Li,Changjian7; Zhang,Hui2; Xu,Pengfei1; Hu,Zhenhua3,8; Tian,Jie3,7,8,9
刊名Journal of Nanobiotechnology
出版日期2022-03-19
卷号20期号:1
关键词Aggregation-induced emission NIR-II imaging Phototherapy Phototheranostic Residual tumor
DOI10.1186/s12951-022-01325-9
通讯作者Zhang,Hui(zhang_hui@sxmu.edu.cn) ; Xu,Pengfei(pengfeixuscu@outlook.com) ; Hu,Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian,Jie(jie.tian@ia.ac.cn)
英文摘要AbstractIncomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1–π–A–D2–R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2?mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes.Graphic Abstract
语种英语
WOS记录号BMC:10.1186/S12951-022-01325-9
出版者BioMed Central
源URL[http://ir.ia.ac.cn/handle/173211/47642]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Zhang,Hui; Xu,Pengfei; Hu,Zhenhua; Tian,Jie
作者单位1.Jining Medical University; Institute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital
2.First Hospital of Shanxi Medical University; Department of Radiology
3.University of Chinese Academy of Sciences; School of Artificial Intelligence
4.Southern Medical University; Department of Hepatobiliary Surgery, Zhujiang Hospital
5.Anhui Medical University
6.Chinese PLA General Hospital; Department of Gastroenterology, The Third Medical Centre
7.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering
8.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation
9.Shanxi Medical University; College of Medical Imaging
推荐引用方式
GB/T 7714		 Qu,Qiaojun,Zhang,Zeyu,Guo,Xiaoyong,et al. Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor[J]. Journal of Nanobiotechnology,2022,20(1).
APA Qu,Qiaojun.,Zhang,Zeyu.,Guo,Xiaoyong.,Yang,Junying.,Cao,Caiguang.,...&Tian,Jie.(2022).Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor.Journal of Nanobiotechnology,20(1).
MLA Qu,Qiaojun,et al."Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor".Journal of Nanobiotechnology 20.1(2022).

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来源：自动化研究所

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