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Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI

文献类型：期刊论文

作者Jiang, Hanyu13; Wei, Jingwei11,12; Fu, Fangfang9,10; Wei, Hong13; Qin, Yun13; Duan, Ting13; Chen, Weixia13; Xie, Kunlin8; Lee, Jeong Min7,14; Bashir, Mustafa R.4,5,6
刊名LIVER INTERNATIONAL
出版日期2022-03-11
页码15
关键词diagnosis gadoxetate disodium-enhanced MRI hepatocellular carcinoma microvascular invasion survival
ISSN号1478-3223
DOI10.1111/liv.15231
通讯作者Wang, Meiyun(mywang@ha.edu.cn) ; Song, Bin(anicesong@vip.sina.com) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Background & Aims Microvascular invasion (MVI) is an important risk factor in hepatocellular carcinoma (HCC), but its diagnosis mandates postoperative histopathologic analysis. We aimed to develop and externally validate a predictive scoring system for MVI. Methods From July 2015 to November 2020, consecutive patients underwent surgery for HCC with preoperative gadoxetate disodium (EOB)-enhanced MRI was retrospectively enrolled. All MR images were reviewed independently by two radiologists who were blinded to the outcomes. In the training centre, a radio-clinical MVI score was developed via logistic regression analysis against pathology. In the testing centre, areas under the receiver operating curve (AUCs) of the MVI score and other previous MVI schemes were compared. Overall survival (OS) and recurrence-free survival (RFS) were analysed by the Kaplan-Meier method with the log-rank test. Results A total of 417 patients were included, 195 (47%) with pathologically-confirmed MVI. The MVI score included: non-smooth tumour margin (odds ratio [OR] = 4.4), marked diffusion restriction (OR = 3.0), internal artery (OR = 3.0), hepatobiliary phase peritumoral hypointensity (OR = 2.5), tumour multifocality (OR = 1.6), and serum alpha-fetoprotein >400 ng/mL (OR = 2.5). AUCs for the MVI score were 0.879 (training) and 0.800 (testing), significantly higher than those for other MVI schemes (testing AUCs: 0.648-0.684). Patients with model-predicted MVI had significantly shorter OS (median 61.0 months vs not reached, P < .001) and RFS (median 13.0 months vs. 42.0 months, P < .001) than those without. Conclusions A preoperative MVI score integrating five EOB-MRI features and serum alpha-fetoprotein level could accurately predict MVI and postoperative survival in HCC. Therefore, this score may aid in individualized treatment decision making.
WOS关键词COMPUTED-TOMOGRAPHY ; RECURRENCE ; DIAGNOSIS ; RESECTION ; NOMOGRAM ; SYSTEM ; CANCER
资助项目National Natural Science Foundation of China[82101997] ; National Natural Science Foundation of China[62027 901] ; National Natural Science Foundation of China[81 227 901] ; National Natural Science Foundation of China[81 930 053] ; National Natural Science Foundation of China[82 001917] ; Science and Technology Support Program of Sichuan Province[2021YFS0141] ; Science and Technology Support Program of Sichuan Province[2021YFS0021] ; Ministry of Science and Technology of China[2017YFA0205200] ; Project of High-Level Talents Team Introduction in Zhuhai City[HLHPTP201703]
WOS研究方向Gastroenterology & Hepatology
语种英语
WOS记录号WOS:000767145200001
出版者WILEY
资助机构National Natural Science Foundation of China ; Science and Technology Support Program of Sichuan Province ; Ministry of Science and Technology of China ; Project of High-Level Talents Team Introduction in Zhuhai City
源URL[http://ir.ia.ac.cn/handle/173211/47942]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Wang, Meiyun; Song, Bin; Tian, Jie
作者单位1.Beihang Univ, Minist Ind & Informat Technol, Key Lab Big Data Based Precis Med, Beijing, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China
3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China
4.Duke Univ, Med Ctr, Div Gastroenterol, Durham, NC 27710 USA
5.Duke Univ, Med Ctr, Ctr Adv Magnet Resonance Med, Durham, NC USA
6.Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA
7.Seoul Natl Univ, Coll Med, Seoul, South Korea
8.Sichuan Univ, West China Hosp, Dept Liver Surg & Liver Transplantat, Chengdu, Peoples R China
9.Zhengzhou Univ, Dept Med Imaging, Peoples Hosp, Zhengzhou, Peoples R China
10.Henan Prov Peoples Hosp, Dept Med Imaging, Zhengzhou 450003, Henan, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Hanyu,Wei, Jingwei,Fu, Fangfang,et al. Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI[J]. LIVER INTERNATIONAL,2022:15.
APA Jiang, Hanyu.,Wei, Jingwei.,Fu, Fangfang.,Wei, Hong.,Qin, Yun.,...&Tian, Jie.(2022).Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI.LIVER INTERNATIONAL,15.
MLA Jiang, Hanyu,et al."Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI".LIVER INTERNATIONAL (2022):15.

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来源：自动化研究所

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