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Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China

文献类型：期刊论文

作者Zhang, Zeyu4,5; He, Kunshan2,3,4; Chi, Chongwei1,4; Hu, Zhenhua1,4; Tian, Jie4,5
刊名EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
出版日期2022-03-01
页码13
ISSN号1619-7070
关键词Molecular imaging Precision surgery Cancer surgery Image-guided surgery Molecular-targeted agents Clinical translation
DOI10.1007/s00259-022-05730-y
通讯作者Chi, Chongwei(chongwei.chi@ia.ac.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(tian@ieee.org)
英文摘要Purpose China has the largest cancer population globally. Surgery is the main choice for most solid cancer patients. Intraoperative fluorescence molecular imaging (FMI) has shown its great potential in assisting surgeons in achieving precise resection. We summarized the typical applications of intraoperative FMI and several new trends to promote the development of precision surgery. Methods The academic database and NIH clinical trial platform were systematically evaluated. We focused on the clinical application of intraoperative FMI in China. Special emphasis was placed on a series of typical studies with new technologies or high-level evidence. The emerging strategy of combining FMI with other modalities was also discussed. Results The clinical applications of clinically approved indocyanine green (ICG), methylene blue (MB), or fluorescein are on the rise in different surgical departments. Intraoperative FMI has achieved precise lesion detection, sentinel lymph node mapping, and lymphangiography for many cancers. Nerve imaging is also exploring to reduce iatrogenic injuries. Through different administration routes, these fluorescent imaging agents provided encouraging results in surgical navigation. Meanwhile, designing new cancer-specific fluorescent tracers is expected to be a promising trend to further improve the surgical outcome. Conclusions Intraoperative FMI is in a rapid development in China. In-depth understanding of cancer-related molecular mechanisms is necessary to achieve precision surgery. Molecular-targeted fluorescent agents and multi-modal imaging techniques might play crucial roles in the era of precision surgery.
WOS关键词NEAR-INFRARED FLUORESCENCE ; INDOCYANINE GREEN ; GUIDED SURGERY ; HEPATOCELLULAR-CARCINOMA ; GASTRIC-CANCER ; LIVER-CANCER ; LUNG-CANCER ; OPEN-LABEL ; RESECTION ; FEASIBILITY
资助项目National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81930048] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[82102236] ; National Natural Science Foundation of China (NSFC)[82001984] ; National Natural Science Foundation of China (NSFC)[81801864] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Municipal Science & Technology Commission[Z201100006820017] ; Beijing Municipal Science & Technology Commission[Z19111000110000] ; China Postdoctoral Science Foundation[2021M690007] ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703] ; innovative research team of high-level local universities in Shanghai
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者SPRINGER
WOS记录号WOS:000762898800004
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Municipal Science & Technology Commission ; China Postdoctoral Science Foundation ; Zhuhai High-level Health Personnel Team Project ; innovative research team of high-level local universities in Shanghai
源URL[http://ir.ia.ac.cn/handle/173211/47996]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Chi, Chongwei; Hu, Zhenhua; Tian, Jie
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Software, Beijing Key Lab Human Comp Interact, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Software, State Key Lab Comp Sci, Beijing, Peoples R China
4.Chinese Acad Sci, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Inst Automat,State Key Lab Management & Control C, Beijing, Peoples R China
5.Beihang Univ, Sch Engn Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zeyu,He, Kunshan,Chi, Chongwei,et al. Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022:13.
APA Zhang, Zeyu,He, Kunshan,Chi, Chongwei,Hu, Zhenhua,&Tian, Jie.(2022).Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,13.
MLA Zhang, Zeyu,et al."Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022):13.

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来源：自动化研究所

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