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Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial

文献类型：期刊论文

作者He, Kunshan2,3,4,5; Hong, Xiaopeng6; Chi, Chongwei1; Cai, Chaonong6; An, Yu4,5; Li, Peiping6; Liu, Xialei6; Shan, Hong6; Tian, Jie1,4,5; Li, Jian6
刊名JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
出版日期2022-02-01
卷号234期号:2页码:130-137
ISSN号1072-7515
DOI10.1097/XCS.0000000000000029
通讯作者Li, Jian(lijian5@mail.sysu.edu.cn)
英文摘要BACKGROUND: The application of indocyanine green fluorescence-guided hepatectomy for liver metastases from colorectal cancer is in the preliminary stage of clinical practice; thus, its efficacy needs to be determined. This study compared the number of intrahepatic colorectal liver metastases detected intraoperatively and postoperative recovery data between patients who underwent traditional hepatectomy (nonindocyanine green group) and traditional hepatectomy plus intraoperative indocyanine green fluorescence imaging (indocyanine green group). STUDY DESIGN: Between January 2018 and March 2020, patients with potentially resectable colorectal liver metastases were randomly assigned to the nonindocyanine green or indocyanine green group. The number of intrahepatic colorectal liver metastases identified intraoperatively and based on postoperative recovery data were compared between both groups. RESULTS: Overall, we recruited 80 patients, among whom 72 eligible patients were randomly assigned. After allocation, 64 patients, comprising 32 in each group, underwent the allocated intervention and follow-up. Compared with the nonindocyanine green group, the mean number of intrahepatic colorectal liver metastases identified intraoperatively in the indocyanine green group was significantly greater (mean [standard deviation], 3.03 [1.58] vs 2.28 [1.35]; p = 0.045), the postoperative hospital stay was shorter (p = 0.012) and the 1-year recurrence rate was also lower (p = 0.017). Postoperative complications and 90-day mortality were comparable, with no statistical differences. CONCLUSIONS: Indocyanine green fluorescence imaging significantly increases the number of intrahepatic colorectal liver metastases identified and reduces postoperative hospital stay and 1-year recurrence rate without increasing hepatectomy-related complications and mortality rates. (C) 2022 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.
WOS关键词INTRAOPERATIVE ULTRASOUND ; INDOCYANINE GREEN ; RESECTION ; CANCER
资助项目Ministry of Science and Technology of China[2017YFA0205200] ; National Natural Science Foundation of China[81971773] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[82001984] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Municipal Science & Technology Commission[Z201100006820017] ; Beijing Municipal Science & Technology Commission[Z19111000110000] ; Project of High-Level Talents Team Introduction in Zhuhai City[HLHPTP201703]
WOS研究方向Surgery
语种英语
出版者LIPPINCOTT WILLIAMS & WILKINS
WOS记录号WOS:000765911100006
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Project of High-Level Talents Team Introduction in Zhuhai City
源URL[http://ir.ia.ac.cn/handle/173211/47999]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Li, Jian
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Software, Beijing Key Lab Human Comp Interact, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Software, State Key Lab Comp Sci, Beijing, Peoples R China
4.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol, Beijing, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing, Peoples R China
6.Sun Yat Sen Univ, Affiliated Hosp 5, Zhuhai 519099, Peoples R China
推荐引用方式
GB/T 7714		 He, Kunshan,Hong, Xiaopeng,Chi, Chongwei,et al. Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial[J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS,2022,234(2):130-137.
APA He, Kunshan.,Hong, Xiaopeng.,Chi, Chongwei.,Cai, Chaonong.,An, Yu.,...&Li, Jian.(2022).Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial.JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS,234(2),130-137.
MLA He, Kunshan,et al."Efficacy of Near-Infrared Fluorescence-Guided Hepatectomy for the Detection of Colorectal Liver Metastases: A Randomized Controlled Trial".JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 234.2(2022):130-137.

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