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The human mediodorsal thalamus: Organization, connectivity, and function

文献类型：期刊论文

作者Li, Kaixin9,10,11; Fan, Lingzhong7,8,9,10; Cui, Yue7,9,10; Wei, Xuehu6; He, Yini5; Yang, Jiyue7,9,10; Lu, Yuheng7,9,10; Li, Wen7,9,10; Shi, Weiyang7,9,10; Cao, Long4,9,10
刊名NEUROIMAGE
出版日期2022-04-01
卷号249页码:10
ISSN号1053-8119
关键词Mediodorsal thalamic nucleus Parcellation Anatomical organization Functional connectivity Cognitive functions
DOI10.1016/j.neuroimage.2022.118876
通讯作者You, Bo(youbo@hrbust.edu.cn) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要The human mediodorsal thalamic nucleus (MD) is crucial for higher cognitive functions, while the fine anatomical organization of the MD and the function of each subregion remain elusive. In this study, using high-resolution data provided by the Human Connectome Project, an anatomical connectivity-based method was adopted to unveil the topographic organization of the MD. Four fine-grained subregions were identified in each hemisphere, including the medial (MDm), central (MDc), dorsal (MDd), and lateral (MDl), which recapitulated previous cytoarchitectonic boundaries from histological studies. The subsequent connectivity analysis of the subregions also demonstrated distinct anatomical and functional connectivity patterns, especially with the prefrontal cortex. To further evaluate the function of MD subregions, partial least squares analysis was performed to examine the relationship between different prefrontal-subregion connectivity and behavioral measures in 1012 subjects. The results showed subregion-specific involvement in a range of cognitive functions. Specifically, the MDm predominantly subserved emotional-cognition domains, while the MDl was involved in multiple cognitive functions especially cognitive flexibility and inhibition. The MDc and MDd were correlated with fluid intelligence, processing speed, and emotional cognition. In conclusion, our work provides new insights into the anatomical and functional organization of the MD and highlights the various roles of the prefrontal-thalamic circuitry in human cognition.
WOS关键词PREFRONTAL CORTEX ; NUCLEUS ; PROJECTIONS ; ATLAS ; PARCELLATION ; NEURONS
资助项目National Natural Science Foundation of China[91432302] ; National Natural Science Foundation of China[31620103905] ; National Natural Science Foundation of China[82072099] ; National Natural Science Foundation of China[31771076] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; Beijing Municipal Science and Technology Commission[Z161100000216139] ; Beijing Municipal Science and Technology Commission[Z171100000117002] ; Beijing Advanced Discipline Fund ; Guangdong Pearl River Talents Plan[2016ZT06S220] ; McDonnell Center for Systems Neuroscience at Washington University ; [1U54MH091657]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:000752568400006
资助机构National Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Beijing Advanced Discipline Fund ; Guangdong Pearl River Talents Plan ; McDonnell Center for Systems Neuroscience at Washington University
源URL[http://ir.ia.ac.cn/handle/173211/47620]  
专题自动化研究所_脑网络组研究中心
通讯作者You, Bo; Jiang, Tianzi
作者单位1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Guilin Univ Elect Technol, Sch Life & Environm Sci, Guilin 541004, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
5.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
6.Max Planck Inst Human Cognit & Brain Sci, Dept Neuropsychol, Leipzig, Germany
7.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100190, Peoples R China
8.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
9.Chinese Acad Sci Beijing, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
10.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Li, Kaixin,Fan, Lingzhong,Cui, Yue,et al. The human mediodorsal thalamus: Organization, connectivity, and function[J]. NEUROIMAGE,2022,249:10.
APA Li, Kaixin.,Fan, Lingzhong.,Cui, Yue.,Wei, Xuehu.,He, Yini.,...&Jiang, Tianzi.(2022).The human mediodorsal thalamus: Organization, connectivity, and function.NEUROIMAGE,249,10.
MLA Li, Kaixin,et al."The human mediodorsal thalamus: Organization, connectivity, and function".NEUROIMAGE 249(2022):10.

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来源：自动化研究所

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