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Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales

文献类型：期刊论文

作者Long, Haixia10; Fan, Ming9; Li, Qiaojun8; Yang, Xuhua10; Huang, Yujiao7; Xu, Xinli10; Ma, Ji10; Xiao, Jie10; Jiang, Tianzi1,2,3,4,5,6
刊名HUMAN BRAIN MAPPING
出版日期2022-03-15
页码13
关键词aggression subscales functional connectivity gray matter volume insula subregions mediation analysis sex
ISSN号1065-9471
DOI10.1002/hbm.25826
通讯作者Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要Aggression is a common and complex social behavior that is associated with violence and mental diseases. Although sex differences were observed in aggression, the neural mechanism for the effect of sex on aggression behaviors remains unclear, especially in specific subscales of aggression. In this study, we investigated the effects of sex on aggression subscales, gray matter volume (GMV), and functional connectivity (FC) of each insula subregion as well as the correlation of aggression subscales with GMV and FC. This study found that sex significantly influenced (a) physical aggression, anger, and hostility; (b) the GMV of all insula subregions; and (c) the FC of the dorsal agranular insula (dIa), dorsal dysgranular insula (dId), and ventral dysgranular and granular insula (vId_vIg). Additionally, mediation analysis revealed that the GMV of bilateral dIa mediates the association between sex and physical aggression, and left dId-left medial orbital superior frontal gyrus FC mediates the relationship between sex and anger. These findings revealed the neural mechanism underlying the sex differences in aggression subscales and the important role of the insula in aggression differences between males and females. This finding could potentially explain sexual dimorphism in neuropsychiatric disorders and improve dysregulated aggressive behavior.
WOS关键词CALLOUS-UNEMOTIONAL TRAITS ; ANTERIOR INSULA ; CORTICAL THICKNESS ; DEFAULT NETWORK ; BRAIN STRUCTURE ; ANGER ; CONNECTIVITY ; GENDER ; ARCHITECTURE ; METAANALYSIS
资助项目National Natural Science Foundation of China[61773348] ; National Natural Science Foundation of China[61871428] ; National Natural Science Foundation of China[61902350] ; National Natural Science Foundation of China[61972354] ; National Natural Science Foundation of China[62106225] ; National Natural Science Foundation of China[81801687] ; Public Welfare Technology Research Project in Zhejiang Province of China[LGG20F020017] ; Zhejiang Provincial Natural Science Foundation of China[LQ18F030015] ; Zhejiang Provincial Natural Science Foundation of China[LY18F030023]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000768880600001
出版者WILEY
资助机构National Natural Science Foundation of China ; Public Welfare Technology Research Project in Zhejiang Province of China ; Zhejiang Provincial Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/47936]  
专题自动化研究所_脑网络组研究中心
通讯作者Jiang, Tianzi
作者单位1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
2.Univ Elect Sci & Technol China, Clin Hosp, MOE Key Lab Neuroinformat, Chengdu Brain Sci Inst, Chengdu, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
6.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China
7.Zhejiang Univ Technol, Zhijiang Coll, Hangzhou, Peoples R China
8.Tianjin Univ Commerce, Sch Informat Engn, Tianjin, Peoples R China
9.Hangzhou Dianzi Univ, Inst Biomed Engn & Instrumentat, Hangzhou, Peoples R China
10.Zhejiang Univ Technol, Coll Comp Sci & Technol, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Long, Haixia,Fan, Ming,Li, Qiaojun,et al. Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales[J]. HUMAN BRAIN MAPPING,2022:13.
APA Long, Haixia.,Fan, Ming.,Li, Qiaojun.,Yang, Xuhua.,Huang, Yujiao.,...&Jiang, Tianzi.(2022).Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.HUMAN BRAIN MAPPING,13.
MLA Long, Haixia,et al."Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales".HUMAN BRAIN MAPPING (2022):13.

入库方式： OAI收割

来源：自动化研究所

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