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Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

文献类型：期刊论文

作者Wang, Wen-Zhu3,4; Liu, Xu2; Yang, Zheng-Yi1; Wang, Yi-Zheng4; Lu, Hai-Tao4
刊名NEURAL REGENERATION RESEARCH
出版日期2022-04-01
卷号17期号:4页码:838-844
关键词brain-derived neurotrophic factor diffusion tensor imaging fractional anisotropy value global cerebral ischemia/reperfusion injury hippocampus TrkB
ISSN号1673-5374
DOI10.4103/1673-5374.322468
通讯作者Lu, Hai-Tao(13051760807@163.com)
英文摘要At present, predicting the severity of brain injury caused by global cerebral ischemia/reperfusion injury (GCI/RI) is a clinical problem. After such an injury, clinical indicators that can directly reflect neurological dysfunction are lacking. The change in hippocampal microstructure is the key to memory formation and consolidation. Diffusion tensor imaging is a highly sensitive tool for visualizing injury to hippocampal microstructure. Although hippocampal microstructure, brain-derived neurotrophic factor (BDNF), and tropomyosin-related kinase B (TrkB) levels are closely related to nerve injury and the repair process after GCI/RI, whether these indicators can reflect the severity of such hippocampal injury remains unknown. To address this issue, we established rat models of GCI/RI using the four-vessel occlusion method. Diffusion tensor imaging parameters, BDNF, and TrkB levels were correlated with modified neurological severity scores. The results revealed that after GCI/RI, while neurological function was not related to BDNF and TrkB levels, it was related to hippocampal fractional anisotropy. These findings suggest that hippocampal fractional anisotropy can reflect the severity of hippocampal injury after global GCI/RI. The study was approved by the Institutional Animal Care and Use Committee of Capital Medical University, China (approval No. AEEI-2015-139) on November 9, 2015.
WOS关键词NEUROTROPHIC FACTOR BDNF ; REPERFUSION ; DEPRESSION ; MEMORY ; VOLUME
资助项目Fundamental Research Funds for Central Public Welfare Research Institute of China[2015CZ-36] ; Fundamental Research Funds for Central Public Welfare Research Institute of China[2019CZ-7]
WOS研究方向Cell Biology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000754512500031
出版者WOLTERS KLUWER MEDKNOW PUBLICATIONS
资助机构Fundamental Research Funds for Central Public Welfare Research Institute of China
源URL[http://ir.ia.ac.cn/handle/173211/48041]  
专题自动化研究所_脑网络组研究中心
通讯作者Lu, Hai-Tao
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Rehabil Med, Beijing, Peoples R China
3.Beijing Key Lab Neural Injury & Rehabil, Beijing, Peoples R China
4.Capital Med Univ, Beijing Boai Hosp, China Rehabil Res Ctr, Sch Rehabil Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Wen-Zhu,Liu, Xu,Yang, Zheng-Yi,et al. Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2022,17(4):838-844.
APA Wang, Wen-Zhu,Liu, Xu,Yang, Zheng-Yi,Wang, Yi-Zheng,&Lu, Hai-Tao.(2022).Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,17(4),838-844.
MLA Wang, Wen-Zhu,et al."Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 17.4(2022):838-844.

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来源：自动化研究所

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