Mapping blood traits to structural organization of the brain in rhesus monkeys
文献类型：期刊论文
| 作者 | Cui, Yue5,6,7,8 ; Huang, Haibin5,6,7,8; Gao, Jinquan3,4; Jiang, Tianzi2,5,6,7,8; Zhang, Chen1; Yu, Shan5,6,7,8
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| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2022-03-07 |
| 页码 | 11 |
| 关键词 | gray matter hematology rhesus monkey serum biochemistry white matter |
| ISSN号 | 1047-3211 |
| DOI | 10.1093/cercor/bhac065 |
| 通讯作者 | Zhang, Chen() ; Yu, Shan(czhang@ccmu.edu.can) |
| 英文摘要 | Hematological and biochemical blood traits have been linked to brain structural characteristics in humans. However, the relationship between these two domains has not been systematically explored in nonhuman primates, which are crucial animal models for understanding the mechanisms of brain function and developing therapeutics for various disorders. Here we investigated the associations between hematological/biochemical parameters and the brain's gray matter volume and white matter integrity derived from T1-weighted and diffusion magnetic resonance imaging in 36 healthy macaques. We found that intersubject variations in basophil count and hemoglobin levels correlated with gray matter volumes in the anterior cingulum, prefrontal cortex, and putamen. Through interactions between these key elements, the blood parameters' covariation network was linked with that of the brain structures, forming overarching networks connecting blood traits with structural brain features. These networks exhibited hierarchical small-world architecture, indicating highly effective interactions between their constituent elements. In addition, different subnetworks of the brain areas or fiber tracts tended to correlate with unique groups of blood indices, revealing previously unknown brain structural organization. These results provide a quantitative characterization of the interactions between blood parameters and brain structures in macaques and may increase the understanding of the body-brain relationship and the pathogenesis of relevant disorders. |
| WOS关键词 | ALZHEIMERS-DISEASE ; MATTER ; CORTEX ; AGE ; CHOLESTEROL ; COGNITION ; INSIGHTS ; PUTAMEN ; RISK ; SEX |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000767425900001 |
| 出版者 | OXFORD UNIV PRESS INC |
| 源URL | [http://ir.ia.ac.cn/handle/173211/48060]  |
| 专题 | 自动化研究所_脑网络组研究中心 脑图谱与类脑智能实验室 |
| 通讯作者 | Zhang, Chen; Yu, Shan |
| 作者单位 | 1.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Sch Basic Med Sci, Dept Neurobiol,Beijing Key Lab Neural Regenerat &, Beijing 100069, Peoples R China 2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 3.SAFE Pharmaceut Technol Co Ltd, Technol Management Ctr, Beijing 100176, Peoples R China 4.Life Biosci Co Ltd, Model R&D Ctr, Beijing 100176, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 8.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Yue,Huang, Haibin,Gao, Jinquan,et al. Mapping blood traits to structural organization of the brain in rhesus monkeys[J]. CEREBRAL CORTEX,2022:11. |
| APA | Cui, Yue,Huang, Haibin,Gao, Jinquan,Jiang, Tianzi,Zhang, Chen,&Yu, Shan.(2022).Mapping blood traits to structural organization of the brain in rhesus monkeys.CEREBRAL CORTEX,11. |
| MLA | Cui, Yue,et al."Mapping blood traits to structural organization of the brain in rhesus monkeys".CEREBRAL CORTEX (2022):11. |
入库方式： OAI收割
来源：自动化研究所
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