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Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients

文献类型：期刊论文

作者Huang, Jiayuan4,5; Ke, Pengfei4; Chen, Xiaoyi4,5; Li, Shijia4; Zhou, Jing4; Xiong, Dongsheng4; Huang, Yuanyuan1,3; Li, Hehua1,3; Ning, Yuping1,3; Duan, Xujun2
刊名FRONTIERS IN AGING NEUROSCIENCE
出版日期2022-03-03
卷号14页码:11
ISSN号1663-4365
关键词schizophrenia accelerated brain aging brain age gap multimodal magnetic resonance imaging machine learning
DOI10.3389/fnagi.2022.823502
通讯作者Wu, Fengchun(13580380071@163.com) ; Wu, Kai(kaiwu@scut.edu.cn)
英文摘要Accelerated brain aging had been widely reported in patients with schizophrenia (SZ). However, brain aging trajectories in SZ patients have not been well-documented using three-modal magnetic resonance imaging (MRI) data. In this study, 138 schizophrenia patients and 205 normal controls aged 20-60 were included and multimodal MRI data were acquired for each individual, including structural MRI, resting state-functional MRI and diffusion tensor imaging. The brain age of each participant was estimated by features extracted from multimodal MRI data using linear multiple regression. The correlation between the brain age gap and chronological age in SZ patients was best fitted by a positive quadratic curve with a peak chronological age of 47.33 years. We used the peak to divide the subjects into a youth group and a middle age group. In the normal controls, brain age matched chronological age well for both the youth and middle age groups, but this was not the case for schizophrenia patients. More importantly, schizophrenia patients exhibited increased brain age in the youth group but not in the middle age group. In this study, we aimed to investigate brain aging trajectories in SZ patients using multimodal MRI data and revealed an aberrant brain age trajectory in young schizophrenia patients, providing new insights into the pathophysiological mechanisms of schizophrenia.
WOS关键词WHITE-MATTER INTEGRITY ; FUNCTIONAL CONNECTIVITY ; INTERNAL CAPSULE ; TREATMENT-NAIVE ; POSTERIOR LIMB ; DRUG-NAIVE ; 1ST-EPISODE ; ABNORMALITIES ; PREDICTION ; NETWORK
资助项目National Key Research and Development Program of China[2020YFC2004300] ; National Key Research and Development Program of China[2020YFC2004301] ; National Key Research and Development Program of China[2019YFC0118800] ; National Key Research and Development Program of China[2019YFC0118802] ; National Key Research and Development Program of China[2019YFC0118804] ; National Key Research and Development Program of China[2019YFC0118805] ; National Key Research and Development Program of China[2021YFC2009400] ; National Key Research and Development Program of China[2021YFC2009404] ; National Natural Science Foundation of China[31771074] ; National Natural Science Foundation of China[81802230] ; National Natural Science Foundation of China[72174082] ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project[2021B1515020064] ; Key Research and Development Program of Guangdong[2018B030335001] ; Key Research and Development Program of Guangdong[2020B0101130020] ; Key Research and Development Program of Guangdong[2020B0404010002] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201803010100] ; Science and Technology Program of Guangzhou[201903010032] ; Science and Technology Program of Guangzhou[202103000032] ; Key Laboratory Program of Guangdong Provincial Education Department[2020KSYS001] ; Open Fund of the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion[2021B1212040014]
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000784192000001
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project ; Key Research and Development Program of Guangdong ; Science and Technology Program of Guangzhou ; Key Laboratory Program of Guangdong Provincial Education Department ; Open Fund of the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion
源URL[http://ir.ia.ac.cn/handle/173211/48310]  
专题精密感知与控制研究中心_人工智能与机器学习
通讯作者Wu, Fengchun; Wu, Kai
作者单位1.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China
2.Univ Elect Sci & Technol China, MOE Key Lab Neuroinformat, High Field Magnet Resonance Brain Imaging Key Lab, Chengdu, Peoples R China
3.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China
4.South China Univ Technol, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou, Peoples R China
5.South China Univ Technol, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou, Peoples R China
6.Guangdong Second Prov Gen Hosp, Inst Healthcare Artificial Intelligence Applicat, Guangzhou, Peoples R China
7.Guangdong Engn Technol Res Ctr Diag & Rehabil Dem, Guangzhou, Peoples R China
8.South China Univ Technol, Guangdong Prov Key Lab Biomed Engn, Guangzhou, Peoples R China
9.South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou, Peoples R China
10.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Jiayuan,Ke, Pengfei,Chen, Xiaoyi,et al. Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14:11.
APA Huang, Jiayuan.,Ke, Pengfei.,Chen, Xiaoyi.,Li, Shijia.,Zhou, Jing.,...&Wu, Kai.(2022).Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients.FRONTIERS IN AGING NEUROSCIENCE,14,11.
MLA Huang, Jiayuan,et al."Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients".FRONTIERS IN AGING NEUROSCIENCE 14(2022):11.

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