Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy
文献类型：期刊论文
| 作者 | Y. Bian; Y. Jiang; Y. Huang; X. Yang; W. Deng; H. Shen; R. Shen and C. Kuang |
| 刊名 | APL Photonics
 |
| 出版日期 | 2021 |
| 卷号 | 6期号:3 |
| ISSN号 | 23780967 |
| DOI | 10.1063/5.0039206 |
| 英文摘要 | Singlet lenses are free from precise assembling, aligning, and testing, which are helpful for the development of portable and low-cost microscopes. However, balancing the spectrum dispersion or chromatic aberrations using a singlet lens made of one material is difficult. Here, a novel method combining singlet lens microscopy and computational imaging, which is based on deep learning image-style-transfer algorithms, is proposed to overcome this problem in clinical pathological slide microscopy. In this manuscript, a singlet aspheric lens is used, which has a high cut-off frequency and linear signal properties. Enhanced by a trained deep learning network, it is easy to transfer the monochromatic gray-scale microscopy picture to a colorful microscopy picture, with only one single-shot recording by a monochromatic CMOS image sensor. By experiments, data analysis, and discussions, it is proved that our proposed virtual colorization microscope imaging method is effective for H&E stained tumor tissue slides in singlet microscopy. It is believable that the computational virtual colorization method for singlet microscopes would promote the low-cost and portable singlet microscopy development in medical pathological label staining observing (e.g., H&E staining, Gram staining, and fluorescent labeling) biomedical research. 2021 Author(s. |
| URL标识 | 查看原文 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/65127]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 推荐引用方式 GB/T 7714 | Y. Bian,Y. Jiang,Y. Huang,et al. Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy[J]. APL Photonics,2021,6(3). |
| APA | Y. Bian.,Y. Jiang.,Y. Huang.,X. Yang.,W. Deng.,...&R. Shen and C. Kuang.(2021).Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy.APL Photonics,6(3). |
| MLA | Y. Bian,et al."Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy".APL Photonics 6.3(2021). |
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