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Mucin corona delays intracellular trafficking and alleviates cytotoxicity of nanoplastic-benzopyrene combined contaminant

文献类型：期刊论文

作者Ji, Yunxia4,5; Wang, Yunqing2,4; Shen, Dazhong5; Kang, Qi5; Chen, Lingxin1,2,3,4
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2021-03-15
卷号406页码:13
关键词Nanoplastics Combined contamination Protein corona Intracellular trafficking Toxicological effects
ISSN号0304-3894
DOI10.1016/j.jhazmat.2020.124306
通讯作者Kang, Qi(kangqi@sdnu.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Nanoplastics have recently become a worldwide concern as newly emerging airborne pollutants, which can associate with polycyclic aromatic hydrocarbons (PAHs) and form combined contaminant nanoparticles (CCNPs). After being inhaled in the respiratory system, the CCNPs would first encounter the mucous gel layer being rich in mucin. Herein, polystyrene-benzopyrene (PS@Bap) NPs were prepared as CCNPs model and their interaction with mucin and the resultant biological responses were studied. It was observed that mucin corona stably attached to the CCNPs surface, which significantly altered the fate of the CCNPs in lung epithelial cells (A 549 cell line). The mucin corona would 1) stably adsorbed on PS@Bap at the early stages of endocytosis until degraded during the lysosomal transport and maturation process, 2) delay intracellular trafficking of PS@Bap and the progress of Bap detached from PS, 3) enhance uptake of PS@Bap but reduce the cytotoxicity elicited by PS@Bap, as indicated by cell viability, generation of reactive oxygen species, impairment on mitochondrial function, and further cell apoptosis. In addition, in vivo study also verified the enhanced effect of PS on the development of an acute lung inflammatory response induced by Bap. This study highlights the significance of incorporating the effects of mucin for precisely assessing the respiratory system toxicity of nanoplastics based CCNPs in atmospheric environments.
WOS关键词POTENTIAL HEALTH IMPACT ; POLYSTYRENE NANOPARTICLES ; MICROPLASTICS ; MICRO ; ROS ; ACTIVATION ; PARTICLES ; APOPTOSIS ; SORPTION ; BARRIER
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000701704400005
资助机构National Natural Science Foundation of China ; program of Youth Innovation Promotion Association, CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Fund
源URL[http://ir.yic.ac.cn/handle/133337/30759]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Kang, Qi; Chen, Lingxin
作者单位1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
5.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Peoples R China
推荐引用方式
GB/T 7714		 Ji, Yunxia,Wang, Yunqing,Shen, Dazhong,et al. Mucin corona delays intracellular trafficking and alleviates cytotoxicity of nanoplastic-benzopyrene combined contaminant[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,406:13.
APA Ji, Yunxia,Wang, Yunqing,Shen, Dazhong,Kang, Qi,&Chen, Lingxin.(2021).Mucin corona delays intracellular trafficking and alleviates cytotoxicity of nanoplastic-benzopyrene combined contaminant.JOURNAL OF HAZARDOUS MATERIALS,406,13.
MLA Ji, Yunxia,et al."Mucin corona delays intracellular trafficking and alleviates cytotoxicity of nanoplastic-benzopyrene combined contaminant".JOURNAL OF HAZARDOUS MATERIALS 406(2021):13.

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来源：烟台海岸带研究所

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