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Evaluate the bisphenol A-induced redox state in cells, zebrafish and in vivo with a hydrogen peroxide turn-on fluorescent probe

文献类型：期刊论文

作者Huang, Yan5; Yu, Lei4; Lu, Pengpeng5; Wei, Yinghui2; Fu, Lili5; Hou, Junjun2; Wang, Yunqing1,3; Wang, Xiaoyan3,5; Chen, Lingxin1,3,5
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2022-02-15
卷号424页码:9
ISSN号0304-3894
关键词Bisphenol A Environmental pollutant Hydrogen peroxide Fluorescent probe Redox state
DOI10.1016/j.jhazmat.2021.127425
通讯作者Wang, Xiaoyan(wangxy@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Hydrogen peroxide (H2O2) is an important active oxygen species that plays a major role in redox balance and in physiological and pathological processes of various diseases of biological systems. As H2O2 is an endogenous active molecule, fluctuations in H2O2 content are not only affected by the state of biological system itself but also easily affected by Bisphenol A (BPA, a typical estrogenic environmental pollutant) in the external environment. Here, the near-infrared fluorescent probe Cy-NOH2 (lambda(em) = 750 nm) as a tool was synthesized to detect fluctuations in H2O2 content in cells and organisms induced by BPA. High sensitivity and excellent selectivity were found when the probe Cy-NOH2 was used to monitor endogenous H2O2 in vitro. In addition, the expression of H2O2 induced by different concentrations of BPA was able to be detected by the probe. Zebrafish and mice models were induced with different concentrations of BPA, and the H2O2 content showed significant increasing trends in zebrafish and livers of mice with increasing BPA concentrations. This study reveals that the probe Cy-NOH2 can be used as an effective tool to monitor the redox state in vivo under the influence of BPA, which provides a basis for clarifying the mechanisms of BPA in a variety of physiological and pathological processes.
WOS关键词ENDOCRINE DISRUPTORS ; MECHANISM ; EXPOSURE ; MOLECULE ; BEHAVIOR ; HYDROPEROXIDES ; DYSFUNCTION ; OXIDATION ; CHEMICALS ; DESIGN
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000711844900009
源URL[http://ir.yic.ac.cn/handle/133337/30717]  
专题烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Wang, Xiaoyan; Chen, Lingxin
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
2.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
4.Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Weifang 262700, Peoples R China
5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Yan,Yu, Lei,Lu, Pengpeng,et al. Evaluate the bisphenol A-induced redox state in cells, zebrafish and in vivo with a hydrogen peroxide turn-on fluorescent probe[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,424:9.
APA Huang, Yan.,Yu, Lei.,Lu, Pengpeng.,Wei, Yinghui.,Fu, Lili.,...&Chen, Lingxin.(2022).Evaluate the bisphenol A-induced redox state in cells, zebrafish and in vivo with a hydrogen peroxide turn-on fluorescent probe.JOURNAL OF HAZARDOUS MATERIALS,424,9.
MLA Huang, Yan,et al."Evaluate the bisphenol A-induced redox state in cells, zebrafish and in vivo with a hydrogen peroxide turn-on fluorescent probe".JOURNAL OF HAZARDOUS MATERIALS 424(2022):9.

入库方式： OAI收割

来源：烟台海岸带研究所

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