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High-quality reannotation of the king scallop genome reveals no 'gene-rich' feature and evolution of toxin resistance

文献类型：期刊论文

作者Zeng, Qifan5,6; Liu, Jing6; Wang, Chunde1,3,4; Wang, Hao6; Zhang, Lingling6; Hu, Jingjie2,6; Bao, Lisui6; Wang, Shi2,5,6
刊名COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
出版日期2021
卷号19页码:4954-4960
关键词King scallop Genome sequencing Gene annotation Neurotoxin tolerance
ISSN号2001-0370
DOI10.1016/j.csbj.2021.08.0382001-0370/
通讯作者Bao, Lisui(baolisui@ouc.edu.cn) ; Wang, Shi(swang@ouc.edu.cn)
英文摘要ABSTR A C T The king scallop, Pecten maximus is a well-known, commercially important scallop species and is featured with remarkable tolerance to potent phytotoxins such as domoic acid. A high-quality genome can shed light on its biology and innovative evolution of toxin resistance. A reference genome has recently been published for P. maximus, however, it is suspicious that over 67,700 genes are annotated in this genome, which is unexpectedly larger than its close relatives of pectinids. Herein, we provide an improved high-quality chromosome-level reference genome assembly and annotation for the king scallop P. maximus. A final set of 26,995 genes is annotated after carefully checking and curation of the predicted gene models, which significantly improves the accuracy of gene structure information. The large number of gene dupli-cates in the previous genome is mainly distorted by the fragmented annotation. Through integrated genomic, evolutionary and transcriptomic analyses, we reveal that the Phi subfamily of ionotropic gluta-mate receptors (iGluRs) are well preserved in molluscs, and P. maximus experienced the rapid expansion of the Phi class of iGluR (GluF) gene family. The GluF genes exhibit ubiquitously high expression and altered sequence characteristics for ligand selectivity, which may contribute to the remarkable tolerance to neurotoxins in P. maximus. Taken together, our study disapproves the previous claim of the 'gene-rich' genome of this species and provides a high-quality genome assembly for further understanding of its biology and evolution of toxin resistance. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).
WOS关键词PARALYTIC SHELLFISH TOXINS ; DOMOIC ACID ; PREDICTION ; ALIGNMENT ; ALGORITHM ; PROVIDES ; SYSTEM ; CORE ; TOOL
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:000704386800004
资助机构National Natural Science Foundation of China ; Funda-mental Research Funds for the Central Universities ; Project of Sanya Yazhouwan Science and Technology City Manage-ment Foundation ; Taishan Scholar Project Fund of Shandong Province of China
源URL[http://ir.yic.ac.cn/handle/133337/30750]  
专题海岸带生物学与生物资源利用重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Bao, Lisui; Wang, Shi
作者单位1.Qingdao Agr Univ, Qingdao 266109, Peoples R China
2.Ocean Univ China, Sanya Oceanog Inst, Lab Trop Marine Germplasm Resources & Breeding En, Sanya 572000, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
5.Pilot Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
6.Ocean Univ China, Coll Marine Life Sci, MOE Key Lab Marine Genet & Breeding & Sars Fang C, Qingdao 266003, Peoples R China
推荐引用方式
GB/T 7714		 Zeng, Qifan,Liu, Jing,Wang, Chunde,et al. High-quality reannotation of the king scallop genome reveals no 'gene-rich' feature and evolution of toxin resistance[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,2021,19:4954-4960.
APA Zeng, Qifan.,Liu, Jing.,Wang, Chunde.,Wang, Hao.,Zhang, Lingling.,...&Wang, Shi.(2021).High-quality reannotation of the king scallop genome reveals no 'gene-rich' feature and evolution of toxin resistance.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,19,4954-4960.
MLA Zeng, Qifan,et al."High-quality reannotation of the king scallop genome reveals no 'gene-rich' feature and evolution of toxin resistance".COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 19(2021):4954-4960.

入库方式： OAI收割

来源：烟台海岸带研究所

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