Systematic Survey of the Alteration of the Faecal Microbiota in Rats With Gastrointestinal Disorder and Modulation by Multicomponent Drugs
文献类型：期刊论文
| 作者 | Wu, Yue2,3; Wu, Yang1,2; Wu, Hongwei3; Wu, Changxun3; Ji, Enhui3; Xu, Jing3; Zhang, Yi3; Wei, Junying3; Zhao, Yi1; Yang, Hongjun2 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2021-11-02 |
| 卷号 | 12页码:13 |
| 关键词 | XEFP functional dyspepsia intestinal flora metabonomics network pharmacology |
| DOI | 10.3389/fphar.2021.670335 |
| 英文摘要 | Gastrointestinal disorder (GID) is a global health disease which leads to heavy public medical burden. Disorders in the intestinal flora have been found in gastrointestinal disorder patients. However, the interaction between GID and the intestinal flora in faecal has not been studied comprehensively. In addition, multicomponent drugs represented by traditional Chinese medicine (TCM) are widely used for treating GID, but their modulation of the intestinal flora has not been investigated. Therefore, in this study, a high-throughput sequencing strategy was used to investigate alterations in the intestinal flora in a rat GID model, followed by an investigation of the modulation by a representative TCM, Xiaoerfupi (XEFP) granule. The results showed that in rats with GID, the relative abundances of Erysipelotrichaceae, Lachnospiraceae, Streptococcaceae increased and that of Ruminococcaceae decreased. At the macro level, the levels of LysoPC(16:0), LysoPC(20:2), LysoPC(15:0), LysoPC(20:2 (11Z, 14Z)), LysoPC(20:1), LysoPC(15:0), LysoPC(20:0) and LysoPE (0:0/20:0) in serum increased and levels of PC(36:4), PC(38:4), PC(o-36;4), PE (MonoMe(13,5)/MonoMe(11,5)) decreased. The imbalance of metabolites was restored by XEFP through ether lipid metabolism pathway. Increase in the phyla Firmicutes/Bacteroidetes (F/B) ratio of the GID rats was restored by XEFP as well. Moreover, XEFP can relief the symptoms of GID rats by increasing bacteria Ruminococcaceae and decreasing Streptococcaceae, Erysipelotrichaceae and Lachnospiraceae in faecal microbiota level. This study represents a comprehensive survey of the interaction between GID and the intestinal flora and a systematic evaluation of modulation by a multicomponent drug. |
| 资助项目 | Strategic Scientific and Technological Project of Hunan Province[2016GK4050] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000719825800001 |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/18095]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Wei, Junying; Zhao, Yi; Yang, Hongjun |
| 作者单位 | 1.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 2.Chinese Acad Tradit Chinese Med, Med Expt Ctr, Beijing, Peoples R China 3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yue,Wu, Yang,Wu, Hongwei,et al. Systematic Survey of the Alteration of the Faecal Microbiota in Rats With Gastrointestinal Disorder and Modulation by Multicomponent Drugs[J]. FRONTIERS IN PHARMACOLOGY,2021,12:13. |
| APA | Wu, Yue.,Wu, Yang.,Wu, Hongwei.,Wu, Changxun.,Ji, Enhui.,...&Yang, Hongjun.(2021).Systematic Survey of the Alteration of the Faecal Microbiota in Rats With Gastrointestinal Disorder and Modulation by Multicomponent Drugs.FRONTIERS IN PHARMACOLOGY,12,13. |
| MLA | Wu, Yue,et al."Systematic Survey of the Alteration of the Faecal Microbiota in Rats With Gastrointestinal Disorder and Modulation by Multicomponent Drugs".FRONTIERS IN PHARMACOLOGY 12(2021):13. |
入库方式： OAI收割
来源：计算技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。