Social exclusion—being rejected or ignored by individuals or groups—is a common and adverse experience in social life. As a social activity, driving behaviour can be influenced by many factors. Whether social exclusion is one of these factors is an open question. Therefore, the aim of this study is to explore the impact of the social exclusion experience on individuals and their driving behaviours and the mediating effect of prosocial tendencies and driving anger. A total of 240 (104 males and 136 females) participants from China completed a questionnaire including the Ostracism Experiences Scale (OES), the prosocial tendencies measure (PTM), the Driving Anger Scale (DAS) and the Driver Behaviour Questionnaire (DBQ). The hierarchical multiple regression analysis and pathway analysis results showed that social exclusion experience and driving anger positively predicted aberrant driving behaviours (including aggressive violations, ordinary violations, lapses and errors), while prosocial tendencies had a negative impact on aberrant driving behaviour. Moreover, prosocial tendencies and driving anger mediated the relationship between social exclusion and driver behaviour, accounting for 11.18% and 46.71% of the total effect, respectively. The chain-mediated effect of prosocial tendencies and driving anger was also significant, accounting for 5.26% of the total effect of social exclusion on driver behaviour. This study examines the mechanisms underlying social exclusion experiences that positively predict individuals’ unsafe driving behaviours, thereby filling a gap in social exclusion research and suggesting new avenues of exploration into the personal and social influences that affect driving behaviours.