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Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

文献类型：期刊论文

作者Shi, Xiaohan9; Li, Yunguang7,8; Yuan, Qiuyue5,6; Tang, Shijie7,8; Guo, Shiwei9; Zhang, Yehan9; He, Juan7,8; Zhang, Xiaoyu7,8; Han, Ming7,8; Liu, Zhuang7,9
刊名NATURE COMMUNICATIONS
出版日期2022-04-21
卷号13期号:1页码:16
DOI10.1038/s41467-022-29857-6
英文摘要Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, the chromatin accessibility landscape and gene regulatory network of pancreatic cancer are largely uncharacterized. Here, we integrate the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data and the results of drug sensitivity analysis of 283 epigenetic-related chemicals and 5 chemotherapeutic drugs. We identify distinct transcription factors that distinguish molecular subtypes of pancreatic cancer, predict numerous chromatin accessibility peaks associated with gene regulatory networks, discover regulatory noncoding mutations with potential as cancer drivers, and reveal the chromatin accessibility signatures associated with drug sensitivity. These results not only provide the chromatin accessibility atlas of pancreatic cancer but also suggest a systematic approach to comprehensively understand the gene regulatory network of pancreatic cancer in order to advance diagnosis and potential personalized medicine applications. The chromatin accessibility landscape and gene regulatory network of pancreatic cancer has not been fully characterised. Here, the authors perform multi-omics analysis of 84 pancreatic cancer organoid lines and reveal gene regulatory networks and distinct molecular subtypes.
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020905] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB38040400] ; National key research and development program of China[2017YFA0505500] ; National key research and development program of China[2020YFA0509000] ; National key research and development program of China[2020YFA0712402] ; Basic Frontier Science Research Program of Chinese Academy of Sciences[ZDBS-LY-SM015] ; National Natural Science Foundation of China[32125013] ; National Natural Science Foundation of China[81830054] ; National Natural Science Foundation of China[81772723] ; National Natural Science Foundation of China[31930022] ; National Natural Science Foundation of China[31771476] ; National Natural Science Foundation of China[12131020] ; National Natural Science Foundation of China[12026608] ; National Natural Science Foundation of China[82002559] ; National Natural Science Foundation of China[82172589] ; National Natural Science Foundation of China[81972913] ; National Natural Science Foundation of China[82172712] ; National Natural Science Foundation of China[12025107] ; National Natural Science Foundation of China[11871463] ; National Natural Science Foundation of China[61621003] ; Shanghai Science and Technology Committee[21XD1424200] ; Shanghai Science and Technology Committee[21ZR1470100] ; Shanghai Science and Technology Committee[20ZR1456500] ; Shanghai Science and Technology Committee[20511101200] ; JST Moonshot RD[JPMJMS2021] ; Shanghai ShenKang hospital development center[SHDC2020CR2001A]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PORTFOLIO
WOS记录号WOS:000785003900011
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/60378]  
专题应用数学研究所
通讯作者Chen, Luonan; Wang, Yong; Jin, Gang; Gao, Dong
作者单位1.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
2.Guangdong Inst Intelligence Sci & Technol, Zhuhai 519031, Guangdong, Peoples R China
3.Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
5.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, HCMS,NCMIS,CEMS, Beijing 100080, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,Shanghai Key Lab Mol Andr, Shanghai 200031, Peoples R China
9.Naval Med Univ, Changhai Hosp, Dept Hepatobiliary Pancreat Surg, Mil Med Univ 2, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Xiaohan,Li, Yunguang,Yuan, Qiuyue,et al. Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity[J]. NATURE COMMUNICATIONS,2022,13(1):16.
APA Shi, Xiaohan.,Li, Yunguang.,Yuan, Qiuyue.,Tang, Shijie.,Guo, Shiwei.,...&Gao, Dong.(2022).Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.NATURE COMMUNICATIONS,13(1),16.
MLA Shi, Xiaohan,et al."Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity".NATURE COMMUNICATIONS 13.1(2022):16.

入库方式： OAI收割

来源：数学与系统科学研究院

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