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Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model

文献类型：期刊论文

作者Dong, Xingchen1,2,3; Li, Huanhuan2; Pei, Min2; Tan, Jie2; Chen, Ganjun2; Li, Santai2; Xie, Zuobin4; Wang, Qi3; Wang, Guifeng3; Chen, Yi-Li2,4
刊名FEBS OPEN BIO
出版日期2022-05-03
页码11
关键词diabetic neuralgia neuropathic pain nerve growth factor monoclonal antibody analgesia
ISSN号2211-5463
DOI10.1002/2211-5463.13410
通讯作者Chen, Yi-Li(Cheny@dartsbio.com) ; Wang, Chunhe(wangc@simm.ac.cn)
英文摘要Current treatment options for diabetic neuralgia are limited and unsatisfactory. Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain, chronic low back pain, cancer pain induced by bone metastasis, and diabetic neuralgia. However, the clinical development of tanezumab has been terminated due to the risk of induction of rapidly progressive osteoarthritis (RPOA), and no other NGF antibodies have been examined for their ability to treat diabetic neuralgia in either animal models or clinical trials. In this study, a humanized high-affinity NGF monoclonal antibody (mAb), huAb45 that could neutralize the interaction between NGF and its high-affinity receptor TrkA. In a mouse diabetic neuralgia model, it effectively relieved neuropathic pain. This study may serve as the necessary foundation for future studies of huAb45 to potentially treat diabetic neuralgia.
WOS关键词GABAPENTIN ; PREGABALIN ; TANEZUMAB
资助项目National Major Scientific and Technological Special Project[2019ZX09732002-006] ; National Natural Science Foundation of China[81872785] ; National Natural Science Foundation of China[81673347] ; Shanghai Municipal Commission of Science and Technology of China[17431904400] ; Shanghai Municipal Commission of Science and Technology of China[19YF1457400] ; Shanghai Municipal Commission of Science and Technology of China[21S11904500] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120202007] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120202008] ; Major Scientific and Technological Special ProjectofZhongshan City[191022172638719] ; Major Scientific and Technological Special ProjectofZhongshan City[210205143867019]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000789785400001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/299295]  
专题中国科学院上海药物研究所
通讯作者Chen, Yi-Li; Wang, Chunhe
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Jiangsu, Peoples R China
2.Shanghai Mabstone Biotechnol Ltd, Shanghai, Peoples R China
3.Chinese Acad Sci, Biotherapeut Discovery Res Ctr, Shanghai Inst Mat Med, Shanghai, Peoples R China
4.Dartsbio Pharmaceut Ltd, Zhongshan, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Xingchen,Li, Huanhuan,Pei, Min,et al. Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model[J]. FEBS OPEN BIO,2022:11.
APA Dong, Xingchen.,Li, Huanhuan.,Pei, Min.,Tan, Jie.,Chen, Ganjun.,...&Wang, Chunhe.(2022).Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model.FEBS OPEN BIO,11.
MLA Dong, Xingchen,et al."Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model".FEBS OPEN BIO (2022):11.

入库方式： OAI收割

来源：上海药物研究所

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