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Non-coding RNAs: New players in mitophagy and neurodegeneration

文献类型：期刊论文

作者Tai, Yusi1,2; Chen, Jing2; Tao, Zhouteng2; Ren, Jin1,2
刊名NEUROCHEMISTRY INTERNATIONAL
出版日期2022
卷号152页码:14
关键词Mitophagy Non-coding RNA MicroRNA Long non-coding RNA Neurodegenerative diseases
ISSN号0197-0186
DOI10.1016/j.neuint.2021.105253
通讯作者Tao, Zhouteng(taozhouteng@simm.ac.cn) ; Ren, Jin(jren@cdser.simm.ac.cn)
英文摘要Mitophagy controls mitochondrial quality to maintain cellular homeostasis, while aberrations in this process are responsible for neurodegenerative diseases. Mitophagy is initiated through the recruitment of autophagosomes in a ubiquitin-dependent or ubiquitin-independent manner under different stress conditions. Although the detailed molecular mechanisms of how mitophagy processes influence neurodegeneration remain largely uncharacterized, there is mounting evidence indicating that non-coding RNAs (ncRNAs), a variety of endogenous regulators, including microRNAs and long non-coding RNAs, extensively participate in mitophagy processes and play pivotal roles in the aging process and neurodegenerative diseases. Here, we reviewed the major mitophagy pathways modulated by some classical and newly found ncRNAs and summarized the diverse mechanisms in a regulatory network. We also discussed the generalizability of ncRNAs in the development of common neurodegenerative diseases related to proteotoxicity and the importance of mitophagy in the pathogenesis of these diseases. In summary, we propose that ncRNAs act as linkers between mitophagy and neurodegeneration, showing the potential therapeutic application of mitophagy regulation mediated by ncRNAs in neurodegenerative diseases.
WOS关键词INDUCED PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; PROMOTES AUTOPHAGY ; ALPHA-SYNUCLEIN ; MESSENGER-RNA ; MITOCHONDRIAL METABOLISM ; HUNTINGTONS-DISEASE ; MEDIATED MITOPHAGY ; IN-VITRO ; PINK1
资助项目Science and Technology Commission of Shanghai Municipality, China[21ZR1475100]
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000779902000003
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/299481]  
专题新药研究国家重点实验室
通讯作者Tao, Zhouteng; Ren, Jin
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Tai, Yusi,Chen, Jing,Tao, Zhouteng,et al. Non-coding RNAs: New players in mitophagy and neurodegeneration[J]. NEUROCHEMISTRY INTERNATIONAL,2022,152:14.
APA Tai, Yusi,Chen, Jing,Tao, Zhouteng,&Ren, Jin.(2022).Non-coding RNAs: New players in mitophagy and neurodegeneration.NEUROCHEMISTRY INTERNATIONAL,152,14.
MLA Tai, Yusi,et al."Non-coding RNAs: New players in mitophagy and neurodegeneration".NEUROCHEMISTRY INTERNATIONAL 152(2022):14.

入库方式： OAI收割

来源：上海药物研究所

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