Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species
文献类型：期刊论文
| 作者 | Wang, Yingying1,3; Yao, Changliang3; Wang, Mengyuan2,3; Li, Jiayuan3; Li, Zhenwei3; Zhang, Jianqing3; Wei, Wenlong3; Bi, Qirui3; Guo, De-an1,2,3
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| 刊名 | PHYTOCHEMICAL ANALYSIS
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| 出版日期 | 2022-05-01 |
| 页码 | 10 |
| 关键词 | Achyranthes characterization Cyathula saponins UPLC-Q-TOF-MS |
| ISSN号 | 0958-0344 |
| DOI | 10.1002/pca.3128 |
| 通讯作者 | Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Introduction Achyranthes bidentata Blume (AB) has been used for a long time and is recorded in the Chinese Pharmacopoeia 2020 edition. It is commonly confused with Achyranthes aspera Linn (AA), Cyathula officinalis Kuan (CO) and Cyathula capitata (Wall.) Moq. (CC), belonging to the Achyranthes and Cyathula genera of the Amaranthaceae family. It is of great significance to recognize and distinguish chemical components of AB, AA, CO and CC. Objective The purpose of this study was to develop an analytical method for in-depth characterization and comparison of saponins in AB, AA, CO and CC. Methods The extracts of AB, AA, CO and CC were analyzed by an RP x RP (C18 x Phenyl-Hexyl) 2D LC system, eluted by acidic x ion pair mobile phases and detected by high resolution mass spectrometry. Fragmentation patterns of saponins were elucidated and proposed according to reference compounds or literature reports. Results As a result, 839 saponins consisting of 81, 415, 99 and 392 components corresponding to AB, AA, CO and CC, respectively, were characterized, including 594 potentially new saponins. Meanwhile, 29 kinds of aglycones were elucidated, among which 25 were new ones. Besides, 14, 91, 37 and 174 characteristic potential quality markers with MS intensities exceeding 10,000 were found in AB, AA, CO and CC, respectively. Conclusion This comprehensive study not only expands our knowledge of the types of saponins in Achyranthes and Cyathula, but also reveals the differences among four kinds of analogous herbs (AB, AA, CO and CC), which facilitates the quality control of these herbal medicines in the future. |
| WOS关键词 | CHROMATOGRAPHY ; CHONDROCYTES ; APOPTOSIS ; RADIX |
| 资助项目 | Qihuang Chief Scientist Program of National Administration of Traditional Chinese Medicine ; National Natural Science Foundation of China[82130111] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000789113000001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299487]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yingying,Yao, Changliang,Wang, Mengyuan,et al. Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species[J]. PHYTOCHEMICAL ANALYSIS,2022:10. |
| APA | Wang, Yingying.,Yao, Changliang.,Wang, Mengyuan.,Li, Jiayuan.,Li, Zhenwei.,...&Guo, De-an.(2022).Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species.PHYTOCHEMICAL ANALYSIS,10. |
| MLA | Wang, Yingying,et al."Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species".PHYTOCHEMICAL ANALYSIS (2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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