Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1 alpha Pathway
文献类型：期刊论文
| 作者 | Chen, Dandan1,2; Duan, Yanan2; Yu, Shuxiang1; Zhang, Xinwen2; Li, Ni2; Li, Jingya2
|
| 刊名 | PHARMACEUTICALS
 |
| 出版日期 | 2022-04-01 |
| 卷号 | 15期号:4页码:18 |
| 关键词 | obesity rutaecarpine adipocytes thermogenesis peroxisome-proliferator-activated receptor gamma co-activator-1 alpha AMP-activated protein kinase browning |
| DOI | 10.3390/ph15040469 |
| 通讯作者 | Li, Jingya(jyli@simm.ac.cn) |
| 英文摘要 | Pharmacological activation of adaptive thermogenesis to increase energy expenditure is considered to be a novel strategy for obesity. Peroxisome-proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), which serves as an inducible co-activator in energy expenditure, is highly expressed in brown adipose tissues (BAT). In this study, we found a PGC-1 alpha transcriptional activator, natural compound rutaecarpine (Rut), which promoted brown adipocytes mitochondrial biogenesis and thermogenesis in vitro. Chronic Rut treatment reduced the body weight gain and mitigated insulin sensitivity through brown and beige adipocyte thermogenesis. Mechanistic study showed that Rut activated the energy metabolic pathway AMP-activated protein kinase (AMPK)/PGC-1 alpha axis, and deficiency of AMPK abolished the beneficial metabolic phenotype of the Rut treatment in vitro and in vivo. In summary, a PGC-1 alpha transcriptional activator Rut was found to activate brown and beige adipose thermogenesis to resist diet-induced obesity through AMPK pathway. Our findings serve as a further understanding of the natural compound in adipose tissue and provides a possible strategy to combat obesity and related metabolic disorders. |
| WOS关键词 | BROWN FAT THERMOGENESIS ; ACTIVATED RECEPTOR ; PPAR-GAMMA ; MITOCHONDRIAL BIOGENESIS ; COACTIVATOR PGC-1-ALPHA ; ENERGY-EXPENDITURE ; PGC-1 COACTIVATORS ; RETINOIC ACID ; WHITE FAT ; TISSUE |
| 资助项目 | Central Asian Drug Discovery and Development Center of CAS[CAM202001] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000786720000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299490]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jingya |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Dandan,Duan, Yanan,Yu, Shuxiang,et al. Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1 alpha Pathway[J]. PHARMACEUTICALS,2022,15(4):18. |
| APA | Chen, Dandan,Duan, Yanan,Yu, Shuxiang,Zhang, Xinwen,Li, Ni,&Li, Jingya.(2022).Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1 alpha Pathway.PHARMACEUTICALS,15(4),18. |
| MLA | Chen, Dandan,et al."Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1 alpha Pathway".PHARMACEUTICALS 15.4(2022):18. |
入库方式： OAI收割
来源：上海药物研究所
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