Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody
文献类型：期刊论文
| 作者 | Yin, Wanchao2; Xu, Youwei2; Xu, Peiyu2; Cao, Xiaodan3; Wu, Canrong2; Gu, Chunyin3; He, Xinheng2,4; Wang, Xiaoxi2; Huang, Sijie2; Yuan, Qingning5 |
| 刊名 | SCIENCE
 |
| 出版日期 | 2022-03-04 |
| 卷号 | 375期号:6584页码:1048-+ |
| ISSN号 | 0036-8075 |
| DOI | 10.1126/science.abn8863 |
| 通讯作者 | Deng, Su-Jun(dengsujun@jemincare.com) ; Xu, H. Eric(eric.xu@simm.ac.cn) |
| 英文摘要 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant infective strain. We report the structures of the Omicron spike trimer on its own and in complex with angiotensin-converting enzyme 2 (ACE2) or an anti-Omicron antibody. Most Omicron mutations are located on the surface of the spike protein and change binding epitopes to many current antibodies. In the ACE2-binding site, compensating mutations strengthen receptor binding domain (RBD) binding to ACE2. Both the RBD and the apo form of the Omicron spike trimer are thermodynamically unstable. An unusual RBD-RBD interaction in the ACE2-spike complex supports the open conformation and further reinforces ACE2 binding to the spike trimer. A broad-spectrum therapeutic antibody, JMB2002, which has completed a phase 1 clinical trial, maintains neutralizing activity against Omicron. JMB2002 binds to RBD differently from other characterized antibodies and inhibits ACE2 binding. |
| WOS关键词 | CRYO-EM STRUCTURE ; SARS-COV-2 SPIKE ; MODEL |
| 资助项目 | Ministry of Science and Technology of China[2018YFA0507002] ; Shanghai Municipal Science and Technology Major Project[2019SHZDZX02] ; CAS Strategic Priority Research Program[XDB37030103] ; National Natural Science Foundation of China[32171189] ; National Natural Science Foundation of China[32130022] ; National Natural Science Foundation of China[31770796] ; National Natural Science Foundation of China[81902085] ; Youth Innovation Promotion Association of CAS[2021278] ; National Science Fund for Excellent Young Scholars[82122067] ; Fund of Youth Innovation Promotion Association[2018319 Y8G7011009] ; Science and Technology Commission of Shanghai Municipal[20431900100] ; Jack Ma Foundation[2020-CMKYGG-05] ; National Science and Technology Major Project[2018ZX09711002] ; China Postdoctoral Science Foundation[E11289R078] ; Key Tasks of LG Laboratory[LG202103-03-05] ; Key Tasks of LG Laboratory[LG202101-01-03] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| WOS记录号 | WOS:000764236900050 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299496]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Deng, Su-Jun; Xu, H. Eric |
| 作者单位 | 1.Chinese Acad Sci, Immunol Dis Res Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Shanghai Jemincare Pharmaceut Co Ltd, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Adv Electron Microscope Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Wanchao,Xu, Youwei,Xu, Peiyu,et al. Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody[J]. SCIENCE,2022,375(6584):1048-+. |
| APA | Yin, Wanchao.,Xu, Youwei.,Xu, Peiyu.,Cao, Xiaodan.,Wu, Canrong.,...&Xu, H. Eric.(2022).Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody.SCIENCE,375(6584),1048-+. |
| MLA | Yin, Wanchao,et al."Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody".SCIENCE 375.6584(2022):1048-+. |
入库方式： OAI收割
来源：上海药物研究所
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