Abnormal global alternative RNA splicing in COVID-19 patients
文献类型：期刊论文
| 作者 | Wang, Changli2; Chen, Lijun2; Chen, Yaobin3; Jia, Wenwen4; Cai, Xunhui3; Liu, Yufeng3; Ji, Fenghu3; Xiong, Peng3; Liang, Anyi3; Liu, Ren5 |
| 刊名 | PLOS GENETICS
 |
| 出版日期 | 2022-04-01 |
| 卷号 | 18期号:4页码:22 |
| ISSN号 | 1553-7404 |
| DOI | 10.1371/journal.pgen.1010137 |
| 通讯作者 | Li, Zhendong(biolzd@foxmail.com) ; Xia, Han(xiahan@hugobiotech.com) ; Xia, Tian(tianxia@hust.edu.cn) |
| 英文摘要 | Viral infections can alter host transcriptomes by manipulating host splicing machinery. Despite intensive transcriptomic studies on SARS-CoV-2, a systematic analysis of alternative splicing (AS) in severe COVID-19 patients remains largely elusive. Here we integrated proteomic and transcriptomic sequencing data to study AS changes in COVID-19 patients. We discovered that RNA splicing is among the major down-regulated proteomic signatures in COVID-19 patients. The transcriptome analysis showed that SARS-CoV-2 infection induces widespread dysregulation of transcript usage and expression, affecting blood coagulation, neutrophil activation, and cytokine production. Notably, CD74 and LRRFIP1 had increased skipping of an exon in COVID-19 patients that disrupts a functional domain, which correlated with reduced antiviral immunity. Furthermore, the dysregulation of transcripts was strongly correlated with clinical severity of COVID-19, and splice-variants may contribute to unexpected therapeutic activity. In summary, our data highlight that a better understanding of the AS landscape may aid in COVID-19 diagnosis and therapy. |
| WOS关键词 | VIRUS ; CELLS ; RESPONSES ; DOCKING ; WEB |
| 资助项目 | Ministry of Science and Technology of P. R. China Plan[2020YFC0844700] ; National Natural Science Foundation of China[61571202] |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| WOS记录号 | WOS:000786606400002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299502]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Zhendong; Xia, Han; Xia, Tian |
| 作者单位 | 1.Baylor Coll Med, Dept Med, Houston, TX USA 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan, Peoples R China 3.Huazhong Univ Sci & Technol, Inst Artificial Intelligence & Automat, Wuhan, Peoples R China 4.Tongji Univ, Shanghai East Hosp, Inst Regenerat Med, Sch Life Sci & Technol, Shanghai, Peoples R China 5.Hugobiotech Co Ltd, Dept Res & Dev, Beijing, Peoples R China 6.Jingjie PTM BioLab Hangzhou Co Ltd, Hangzhou, Peoples R China 7.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai, Peoples R China 9.Elongevity INC, Wuhan, Peoples R China 10.Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX USA |
| 推荐引用方式 GB/T 7714 | Wang, Changli,Chen, Lijun,Chen, Yaobin,et al. Abnormal global alternative RNA splicing in COVID-19 patients[J]. PLOS GENETICS,2022,18(4):22. |
| APA | Wang, Changli.,Chen, Lijun.,Chen, Yaobin.,Jia, Wenwen.,Cai, Xunhui.,...&Xia, Tian.(2022).Abnormal global alternative RNA splicing in COVID-19 patients.PLOS GENETICS,18(4),22. |
| MLA | Wang, Changli,et al."Abnormal global alternative RNA splicing in COVID-19 patients".PLOS GENETICS 18.4(2022):22. |
入库方式： OAI收割
来源：上海药物研究所
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