Niosomal Nanocarriers for Enhanced Dermal Delivery of Epigallocatechin Gallate for Protection against Oxidative Stress of the Skin
文献类型：期刊论文
| 作者 | Li, Danhui2; Martini, Nataly2; Wu, Zimei2; Chen, Shuo2; Falconer, James Robert3; Locke, Michelle4; Zhang, Zhiwen1 ; Wen, Jingyuan2
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| 刊名 | PHARMACEUTICS
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| 出版日期 | 2022-04-01 |
| 卷号 | 14期号:4页码:25 |
| 关键词 | niosomes catechin dermal delivery antioxidant activity oxidative stress skin barrier penetration cellular uptake |
| DOI | 10.3390/pharmaceutics14040726 |
| 通讯作者 | Wen, Jingyuan(j.wen@auckland.ac.nz) |
| 英文摘要 | Among green tea catechins, epigallocatechin gallate (EGCG) is the most abundant and has the highest biological activities. This study aims to develop and statistically optimise an EGCG-loaded niosomal system to overcome the cutaneous barriers and provide an antioxidant effect. EGCG-niosomes were prepared by thin film hydration method and statistically optimised. The niosomes were characterised for size, zeta potential, morphology and entrapment efficiency. Ex vivo permeation and deposition studies were conducted using full-thickness human skin. Cell viability, lipid peroxidation, antioxidant enzyme activities after UVA-irradiation and cellular uptake were determined. The optimised niosomes were spherical and had a relatively uniform size of 235.4 +/- 15.64 nm, with a zeta potential of -45.2 +/- 0.03 mV and an EE of 53.05 +/- 4.46%. The niosomes effectively prolonged drug release and demonstrated much greater skin penetration and deposition than free EGCG. They also increased cell survival after UVA-irradiation, reduced lipid peroxidation, and increased the antioxidant enzymes' activities in human dermal fibroblasts (Fbs) compared to free EGCG. Finally, the uptake of niosomes was via energy-dependent endocytosis. The optimised niosomes have the potential to be used as a dermal carrier for antioxidants and other therapeutic compounds in the pharmaceutical and cosmetic industries. |
| WOS关键词 | TRANSDERMAL ABSORPTION ENHANCEMENT ; IN-VIVO EVALUATION ; TOPICAL DELIVERY ; ANTIINFLAMMATORY ACTIVITY ; VITRO ; FORMULATION ; GEL ; ENCAPSULATION ; VESICLES ; PHARMACOKINETICS |
| 资助项目 | New Zealand Pharmacy Education Foundation (NZPERF)[236] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000786817900001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299505]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wen, Jingyuan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Auckland, Fac Med & Hlth Sci, Sch Pharm, Auckland 1023, New Zealand 3.Univ Queensland, Pharm Australia Ctr Excellence, Sch Pharm, Dept Plast, Brisbane, Qld 4102, Australia 4.Middlemore Hosp, Counties Manukau Dist Hlth Board, Reconstruct Surg, Auckland 2104, New Zealand |
| 推荐引用方式 GB/T 7714 | Li, Danhui,Martini, Nataly,Wu, Zimei,et al. Niosomal Nanocarriers for Enhanced Dermal Delivery of Epigallocatechin Gallate for Protection against Oxidative Stress of the Skin[J]. PHARMACEUTICS,2022,14(4):25. |
| APA | Li, Danhui.,Martini, Nataly.,Wu, Zimei.,Chen, Shuo.,Falconer, James Robert.,...&Wen, Jingyuan.(2022).Niosomal Nanocarriers for Enhanced Dermal Delivery of Epigallocatechin Gallate for Protection against Oxidative Stress of the Skin.PHARMACEUTICS,14(4),25. |
| MLA | Li, Danhui,et al."Niosomal Nanocarriers for Enhanced Dermal Delivery of Epigallocatechin Gallate for Protection against Oxidative Stress of the Skin".PHARMACEUTICS 14.4(2022):25. |
入库方式： OAI收割
来源：上海药物研究所
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