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Reactive Glycolysis Metabolite-Activatable Nanotheranostics for NIR-II Fluorescence Imaging-Guided Phototherapy of Cancer

文献类型：期刊论文

作者Lai, Yi1,2,3; Dang, Yijing2; Li, Fenglin2; Ding, Chunyong4; Yu, Haijun1,3; Zhang, Wen2; Xu, Zhiai2
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2022-03-07
页码13
ISSN号1616-301X
关键词methylglyoxal nanotheranostics NIR-II fluorescence imaging precise cancer therapy tumor metabolism
DOI10.1002/adfm.202200016
通讯作者Zhang, Wen(wzhang@chem.ecnu.edu.cn) ; Xu, Zhiai(zaxu@chem.ecnu.edu.cn)
英文摘要Second near-infrared (NIR-II) fluorescence imaging with deep tissue-penetration ability holds remarkable potential for cancer diagnosis. However, clinical translation of NIR-II fluorescence imaging-based cancer treatment is severely restricted by the low signal-to-background ratio due to insufficient tumor specificity of fluorophores. In this study, it is hypothesized that methylglyoxal (MGO), an intermediate metabolite of tumor glycolysis could be used as a potent biomarker for triggering NIR-II fluorescence imaging-guided cancer theranostic. For proof-of-concept, first a MGO-activatable NIR-II fluorescence probe is developed, and then MGO-responsive "dual lock-and-key" nanotheranostics by integrating the NIR-II fluorophore and a photodynamic prodrug (i.e., hexyl 5-aminolevulinic acid hydrochloride (HAL)) into one nanoparticle is engineered. The nanotheranostic can be specifically activated with tumorous MGO for NIR-II fluorescence imaging-guided combinatory cancer therapy. Upon 808 nm laser irradiation, the activated NIR-II fluorophore can generate tunable photothermal effect to trigger HAL release. Subsequently, HAL is converted to protoporphyrin IX inside the tumor cells for 655 nm laser irradiation-induced photodynamic therapy. It is demonstrated that the NIR-II fluorescence nanotheranostics is highly specifically activated in the tumor and efficiently suppressed 4T1 breast tumor growth in mouse model. The NIR-II fluorescence imaging-based nanotheranostic might imply novel insight into reactive metabolite-activatable precise therapy of tumor.
WOS关键词TURN-ON ; NITRIC-OXIDE ; METHYLGLYOXAL ; MOLECULE ; PROBE ; FLUOROPHORES ; DESIGN
资助项目National Natural Science Foundation of China[22074043] ; National Natural Science Foundation of China[22174047] ; National Natural Science Foundation of China[22177068] ; Science and Technology Commission of Shanghai Municipality[20142202800] ; fundamental research funds from the central universities[m20190319]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000788658300001
源URL[http://119.78.100.183/handle/2S10ELR8/299511]  
专题新药研究国家重点实验室
通讯作者Zhang, Wen; Xu, Zhiai
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
推荐引用方式
GB/T 7714		 Lai, Yi,Dang, Yijing,Li, Fenglin,et al. Reactive Glycolysis Metabolite-Activatable Nanotheranostics for NIR-II Fluorescence Imaging-Guided Phototherapy of Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2022:13.
APA Lai, Yi.,Dang, Yijing.,Li, Fenglin.,Ding, Chunyong.,Yu, Haijun.,...&Xu, Zhiai.(2022).Reactive Glycolysis Metabolite-Activatable Nanotheranostics for NIR-II Fluorescence Imaging-Guided Phototherapy of Cancer.ADVANCED FUNCTIONAL MATERIALS,13.
MLA Lai, Yi,et al."Reactive Glycolysis Metabolite-Activatable Nanotheranostics for NIR-II Fluorescence Imaging-Guided Phototherapy of Cancer".ADVANCED FUNCTIONAL MATERIALS (2022):13.

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来源：上海药物研究所

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