中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy

文献类型：期刊论文

作者Guo, Yuanyuan1,2; Zhang, Qiushuang1; Zhu, Qiwen3; Gao, Jing3; Zhu, Xinyuan1; Yu, Haijun3; Li, Yuehua2; Zhang, Chuan1
刊名SCIENCE ADVANCES
出版日期2022-04-01
卷号8期号:16页码:13
ISSN号2375-2548
DOI10.1126/sciadv.abn2941
通讯作者Yu, Haijun(hjyu@simm.ac.cn) ; Li, Yuehua(liyuehua312@163.com) ; Zhang, Chuan(chuanzhang@sjtu.edu.cn)
英文摘要Packaging multiple drugs into a nanocarrier with rational design to achieve synergistic cancer therapy remains a challenge due to the intrinsically varied pharmacodynamics of therapeutic agents. Especially difficult is combining small-molecule drugs and macromolecular biologics. Here, we successfully graft pheophorbide A (PPA) photo-sensitizers on DNA backbone at predesigned phosphorothioate modification sites. The synthesized four PPA-grafted DNAs are assembled into a tetrahedron framework, which further associates with a programmed death ligand-1 (PD-L1) small interfering RNA (siRNA) linker through supramolecular self-assembly to form an siRNA and PPA copackaged nanogel. With dual therapeutic agents inside, the nanogel can photodynamically kill tumor cells and induce remarkable immunogenic cell death. Also, it simultaneously silences the PD-L1 expression of the tumor cells, which substantially promotes the antitumor immune response and leads to an enhanced antitumor efficacy in a synergistic fashion.
WOS关键词PHOTODYNAMIC THERAPY ; ANTITUMOR IMMUNITY ; CHECKPOINT BLOCKADE ; DELIVERY ; IMMUNOTHERAPY ; NANOPARTICLES ; COMBINATION ; GENE
资助项目National Key Research and Development Program of China[2018YFC1106102] ; National Key Research and Development Program of China[2018YFA0902600] ; National Natural Science Foundation of China[51973112] ; National Natural Science Foundation of China[51690151] ; National Natural Science Foundation of China[52103265] ; National Natural Science Foundation of China[81871329] ; Science Foundation of the Shanghai Municipal Science and Technology Commission[18JC1410800] ; Science Foundation of the Shanghai Municipal Science and Technology Commission[19JC1410300]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000786214100037
出版者AMER ASSOC ADVANCEMENT SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/299523]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun; Li, Yuehua; Zhang, Chuan
作者单位1.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Radiol, Sch Med, 600 Yi Shan Rd, Shanghai 200233, Peoples R China
3.Chinese Acad Sci, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Yuanyuan,Zhang, Qiushuang,Zhu, Qiwen,et al. Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy[J]. SCIENCE ADVANCES,2022,8(16):13.
APA Guo, Yuanyuan.,Zhang, Qiushuang.,Zhu, Qiwen.,Gao, Jing.,Zhu, Xinyuan.,...&Zhang, Chuan.(2022).Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy.SCIENCE ADVANCES,8(16),13.
MLA Guo, Yuanyuan,et al."Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy".SCIENCE ADVANCES 8.16(2022):13.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。