Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells
文献类型：期刊论文
| 作者 | Mu, Hong-yan2,3; Gong, Chen-yuan4,5; Zhang, Ru-jun2; Chen, Zhen-hua2; Zhu, Shi-guo1,4,5; Zhao, Wei-min2,3,6
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| 刊名 | BIOORGANIC CHEMISTRY
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| 出版日期 | 2022-02-01 |
| 卷号 | 119页码:12 |
| 关键词 | Euphorbia helioscopia Diterpenoids NK cell-mediated killing NSCLC cells |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2021.105534 |
| 通讯作者 | Zhu, Shi-guo(zhushiguo@shutcm.edu.cn) ; Zhao, Wei-min(wmzhao@simm.ac.cn) |
| 英文摘要 | Fourteen previously undescribed diterpenoids, including an unusual diterpenoid (1) with a 9,10-seco-jatrophane skeleton, ten jatrophane-type diterpenoids (2-11), two lathyrane-type diterpenoids (12, 13), and an abietanetype diterpenoid (14), together with thirty-six known ones (15-50), were isolated from the whole plants of Euphorbia helioscopia L. The structures of the new isolates were characterized by spectroscopic methods, single crystal X-ray diffraction analysis, and computational prediction of ECD and chemical shifts. Thirty-nine abundant diterpenoids were evaluated for their enhancement of NK cell-mediated killing of NSCLC cells. As a result, compounds 24, 33, and 41 were found to significantly enhance the killing activity of NK cells towards H1299luci cells and A549-luci cells at the concentration of 2.5 mu M. |
| WOS关键词 | IN-VITRO ; DITERPENOIDS ; JATROPHANE |
| 资助项目 | National Key Research and Development Program of China[2019YFC1711300] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000788717800009 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299529]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, Shi-guo; Zhao, Wei-min |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Ctr Tradit Chinese Med, Immunol Res Sch Basic Med Sci, Shanghai 201203, Peoples R China 2.Shanghai Inst Mat Med, Chinese Acad Sci, Nat Prod Res Ctr, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Ctr Tradit Chinese Med, Immunol Res Sch Basic Med Sci, Shanghai 201203, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Sch Basic Med Sci, Dept Immunol & Pathogen Biol, Shanghai 201203, Peoples R China 6.Shanghai Inst Mat Med, Chinese Acad Sci, Nat Prod Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Mu, Hong-yan,Gong, Chen-yuan,Zhang, Ru-jun,et al. Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells [J]. BIOORGANIC CHEMISTRY,2022,119:12. |
| APA |
Mu, Hong-yan,Gong, Chen-yuan,Zhang, Ru-jun,Chen, Zhen-hua,Zhu, Shi-guo,&Zhao, Wei-min.(2022). Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells .BIOORGANIC CHEMISTRY,119,12. |
| MLA |
Mu, Hong-yan,et al." Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells ".BIOORGANIC CHEMISTRY 119(2022):12. |
入库方式： OAI收割
来源：上海药物研究所
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