中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China

文献类型：期刊论文

作者Lu, Jiaojiao2,3; Pan, Qiongqun3; Zhou, Jieqiang3; Weng, Yan1; Chen, Kaili1; Shi, Lv3; Zhu, Guanxiu1; Chen, Chunlin1; Li, Liang3; Geng, Meiyu4
刊名JOURNAL OF PHARMACEUTICAL ANALYSIS
出版日期2022-02-01
卷号12期号:1页码:145-155
ISSN号2095-1779
关键词Sodium oligomannate Alzheimer's disease Pharmacokinetics LC-MS MS Oligosaccharide
DOI10.1016/j.jpha.2021.06.001
通讯作者Li, Liang(liliang@green-valley-ri.com) ; Zhang, Zhenqing(z_zhang@suda.edu.cn)
英文摘要The National Medical Products Administration has authorized sodium oligomannate for treating mild-to moderate Alzheimer's disease. In this study, an LC-MS/MS method was developed and validated to quantitate sodium oligomannate in different biomatrices. The plasma pharmacokinetics, tissue distribution, and excretion of sodium oligomannate in Sprague-Dawley rats and beagle dogs were systematically investigated. Despite its complicated structural composition, the absorption, distribution, metabolism, and excretion profiles of the oligosaccharides in sodium oligomannate of different sizes and terminal derivatives were indiscriminate. Sodium oligomannate mainly crossed the gastrointestinal epithelium through paracellular transport following oral administration, with very low oral bioavailability in rats (0.6%-1.6%) and dogs (4.5%-9.3%). Absorbed sodium oligomannate mainly resided in circulating body fluids in free form with minimal distribution into erythrocytes and major tissues. Sodium oligomannate could penetrate the blood-cerebrospinal fluid (CSF) barrier of rats, showing a constant area under the concentration-time curve ratio (CSF/plasma) of approximately 5%. The cumulative urinary excretion of sodium oligomannate was commensurate with its oral bioavailability, supporting that excretion was predominantly renal, whereas no obvious biliary secretion was observed following a single oral dose to bile duct-cannulated rats. Moreover, only 33.7% (male) and 26.3% (female) of the oral dose were recovered in the rat excreta within 96 h following a single oral administration, suggesting that the intestinal flora may have ingested a portion of unabsorbed sodium oligomannate as a nutrient.(c) 2021 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词OLIGOSACCHARIDE SUGAR CHAIN ; ACIDIC OLIGOSACCHARIDE ; RATS
资助项目National Natural Science Foundation of China[81673388] ; Jiangsu Key Labo-ratory of Translational Research and Therapy for Neuro-Psycho-Diseases[BM2013003] ; Priority Academic Pro-gram Development of Jiangsu Higher Education Institutes (PAPD)
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000782638800015
源URL[http://119.78.100.183/handle/2S10ELR8/299532]  
专题新药研究国家重点实验室
通讯作者Li, Liang; Zhang, Zhenqing
作者单位1.Medicilon Preclin Res Shanghai LLC, Shanghai 201299, Peoples R China
2.Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Suzhou 215021, Jiangsu, Peoples R China
3.Shanghai Green Valley Pharm Corp, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Jiaojiao,Pan, Qiongqun,Zhou, Jieqiang,et al. Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China[J]. JOURNAL OF PHARMACEUTICAL ANALYSIS,2022,12(1):145-155.
APA Lu, Jiaojiao.,Pan, Qiongqun.,Zhou, Jieqiang.,Weng, Yan.,Chen, Kaili.,...&Zhang, Zhenqing.(2022).Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China.JOURNAL OF PHARMACEUTICAL ANALYSIS,12(1),145-155.
MLA Lu, Jiaojiao,et al."Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China".JOURNAL OF PHARMACEUTICAL ANALYSIS 12.1(2022):145-155.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。