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Alpinia hainanensis Rhizome Extract Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis: Active Ingredient Investigation and Evaluation

文献类型：期刊论文

作者Ji, Kai-Long2; Wu, Meng-Zhen1; Huang, Chao-Ying1; Gongpan, Pian-Chou2; Sun, Peng2; Sun, Yi-Li1,5; Li, Jia1,3,4,5,6; Xiao, Chun-Fen2; Xu, You-Kai2; Fan, Qing-Fei2
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2022-04-06
卷号70期号:13页码:3989-3999
ISSN号0021-8561
关键词Alpinia hainanensis anti-inflammatory effect ulcerative colitis curcumin-butyrovanillone hybrids NF-kappa B signaling pathway
DOI10.1021/acs.jafc.1c08038
通讯作者Ji, Kai-Long(kl14ji@163.com) ; Sun, Yi-Li(yilisun@simm.ac.cn) ; Song, Qi-Shi(songqs@xtbg.ac.cn)
英文摘要Alpinia hainanensis is an important food spice and ethnic medicine in Southwest China. In this study, we found that the EtOAc-soluble fraction (AHE) of the A. hainanensis rhizome ethanol extract could ameliorate dextran sulfate sodium-induced ulcerative colitis (UC). To explore active constituents, live pairs of previously unreported enantiomers (1-5), together with nine known ones (6-14), were obtained. Structural characterization was achieved by comprehensive spectroscopic methods. Compounds 1 and 2 were new curcumin-butyrovanillone hybrids featuring a rare structural fragment of 2,3-dihyrofuran. The anti-inflammatory activities of isolates were evaluated, and the results indicated that compounds (-)-1, (-)-3, 6, 9, 11, and 12 significantly inhibited the nuclear factor-kappa B signaling pathway. These findings indicate the major active fraction of the A. hainanensis rhizome ethanol extract enriched with diarylheptanoids, flavonoids, phenolics, and their hybrid mixtures, which could he developed as a nutritional and dietary supplement for treating UC.
WOS关键词NF-KAPPA-B ; CARDAMONIN ; ACTIVATION ; CHALCONES
资助项目Yunnan Fundamental Research Projects[202101AU070148] ; Yunnan Fundamental Research Projects[202101AT070057] ; Yunnan Fundamental Research Projects[202101AT070055] ; West Light Foundation of the Chinese Academy of Sciences[Y9XB061K01] ; National Natural Science Foundation of China[81903682] ; Shanghai Science and Technology Committee[19YF1410200] ; Shanghai Municipal Science and Technology Major Project[TM202101H001]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000786591900006
源URL[http://119.78.100.183/handle/2S10ELR8/299535]  
专题新药研究国家重点实验室
通讯作者Ji, Kai-Long; Sun, Yi-Li; Song, Qi-Shi
作者单位1.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Trop Plant Resources & Sustainable Us, Xishuangbanna Trop Bot Garden, Kunming 650223, Yunnan, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
4.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Shandong, Peoples R China
6.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Ji, Kai-Long,Wu, Meng-Zhen,Huang, Chao-Ying,et al. Alpinia hainanensis Rhizome Extract Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis: Active Ingredient Investigation and Evaluation[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(13):3989-3999.
APA Ji, Kai-Long.,Wu, Meng-Zhen.,Huang, Chao-Ying.,Gongpan, Pian-Chou.,Sun, Peng.,...&Song, Qi-Shi.(2022).Alpinia hainanensis Rhizome Extract Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis: Active Ingredient Investigation and Evaluation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(13),3989-3999.
MLA Ji, Kai-Long,et al."Alpinia hainanensis Rhizome Extract Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis: Active Ingredient Investigation and Evaluation".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.13(2022):3989-3999.

入库方式： OAI收割

来源：上海药物研究所

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