Sinuhirtone A, An Uncommon 17,19-Dinorxeniaphyllanoid, and Nine Related New Terpenoids from the Hainan Soft Coral Sinularia hirta
文献类型：期刊论文
| 作者 | Chen, Zi-Hui2,3; Lu, Si-Qi1,2; Han, Guan-Ying1; Li, Xu-Wen2,3,4 ; Guo, Yue-Wei2,3,4
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2022-04-01 |
| 卷号 | 20期号:4页码:15 |
| 关键词 | soft coral Sinularia hirta xeniaphyllanes norditerpenoids stereochemistry |
| DOI | 10.3390/md20040272 |
| 通讯作者 | Han, Guan-Ying(hanguanying@fibiopharma.com) ; Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Chemical investigation of the Hainan soft coral Sinularia hirta resulted in the isolation and identification of a library of sixteen structurally diverse terpenoids, including a dinorditerpenoid with an uncommon 17,19-dinorxeniaphyllane skeleton, namely sinuhirtone A (7), six new xeniaphyllane-type diterpenoids (1-6), one new norxeniaphyllanoid (8), two new norcaryophyllene-type sesquiterpenoids (9 and 10), together with six known related compounds (11-16). Compounds 1-3 are three new furanone-containing xeniaphyllane-type diterpenoids. The structures of the new compounds, including their absolute configurations, were determined by extensive spectroscopic analysis and a series of quantum chemical calculations, including quantum mechanical-nuclear magnetic resonance (QM-NMR), time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD), and optical rotatory dispersion (ORD) methods. A plausible biosynthetic connection between new compounds 1-9 was also proposed. New compounds 2-4, 7, and 8 were evaluated for in vitro cytotoxicity against four cancer cell lines. |
| WOS关键词 | CARYOPHYLLENE-DERIVED TERPENOIDS ; DITERPENOIDS ; GROWTH |
| 资助项目 | National Key Research and Development Program of China[2021YFF0502400] ; Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[82022069] ; Natural Science Foundation of China[42076099] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of CAS[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000787930300001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299548]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Han, Guan-Ying; Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Jinzhou Med Univ, Jinzhou 121001, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zi-Hui,Lu, Si-Qi,Han, Guan-Ying,et al. Sinuhirtone A, An Uncommon 17,19-Dinorxeniaphyllanoid, and Nine Related New Terpenoids from the Hainan Soft Coral Sinularia hirta[J]. MARINE DRUGS,2022,20(4):15. |
| APA | Chen, Zi-Hui,Lu, Si-Qi,Han, Guan-Ying,Li, Xu-Wen,&Guo, Yue-Wei.(2022).Sinuhirtone A, An Uncommon 17,19-Dinorxeniaphyllanoid, and Nine Related New Terpenoids from the Hainan Soft Coral Sinularia hirta.MARINE DRUGS,20(4),15. |
| MLA | Chen, Zi-Hui,et al."Sinuhirtone A, An Uncommon 17,19-Dinorxeniaphyllanoid, and Nine Related New Terpenoids from the Hainan Soft Coral Sinularia hirta".MARINE DRUGS 20.4(2022):15. |
入库方式： OAI收割
来源：上海药物研究所
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