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Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

文献类型：期刊论文

作者Tu, Bin2,3; Gao, Yanrong2,3; Sun, Feifei2,4; Shi, Mingjie2; Huang, Yongzhuo1,2,3,5,6
刊名FRONTIERS IN PHARMACOLOGY
出版日期2022-03-22
卷号13页码:10
关键词tumor metabolism lipid metabolism tumor immunity tumor microenvironment nanotechnology cancer nanomedicine
DOI10.3389/fphar.2022.840440
通讯作者Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME) affect the antitumor responses of immune cells and cause immune evasion. Therefore, targeting lipid metabolism in the TME for enhancing the antitumor effect of immune cells is a promising direction for cancer treatment. Cancer nanomedicine has great potential in regulating tumor metabolism and tumor immunity. This review summarizes the nanotechnology-based strategies for lipid metabolism regulation in the TME for enhanced anticancer immune responses.
WOS关键词CANCER ; CHOLESTEROL ; CELLS ; MICROENVIRONMENT ; ACCUMULATION ; MECHANISMS ; EXPRESSION ; ACID ; RECRUITMENT ; MACROPHAGES
资助项目National Key Research and Development Program of China[2021YFC2400600] ; National Key Research and Development Program of China[2021YFE0103100] ; National Nature Science Foundation of China[81925035] ; National Nature Science Foundation of China[81521005] ; Shanghai Sci-Tech Innovation Initiative[19431903100] ; Shanghai Sci-Tech Innovation Initiative[18430740800]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000779497900001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/299710]  
专题新药研究国家重点实验室
通讯作者Huang, Yongzhuo
作者单位1.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Adv Study, Taizhou, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, SIMM, Zhongshan, Peoples R China
6.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Tu, Bin,Gao, Yanrong,Sun, Feifei,et al. Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity[J]. FRONTIERS IN PHARMACOLOGY,2022,13:10.
APA Tu, Bin,Gao, Yanrong,Sun, Feifei,Shi, Mingjie,&Huang, Yongzhuo.(2022).Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity.FRONTIERS IN PHARMACOLOGY,13,10.
MLA Tu, Bin,et al."Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity".FRONTIERS IN PHARMACOLOGY 13(2022):10.

入库方式： OAI收割

来源：上海药物研究所

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