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A bispecific nanomodulator to potentiate photothermal cancer immunotherapy

文献类型：期刊论文

作者Zhou, Lei2,3,4; Feng, Bing1; Wang, Hao2; Wang, Dangge3,4,5; Li, Yaping3,4,6
刊名NANO TODAY
出版日期2022-06-01
卷号44页码:12
ISSN号1748-0132
关键词Photothermal therapy Cancer immunotherapy Nanoparticles PD-1 PD-L1 Indoleamine 2 3-dioxygenase 1 (IDO-1)
DOI10.1016/j.nantod.2022.101466
通讯作者Wang, Hao(wanghao@sphchina.com) ; Wang, Dangge(dgwang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Photothermal therapy (PTT) has shown great potential in cancer treatment for inducing photothermal ablation and eliciting immune responses. However, PTT-triggered antitumor immunity is severely hampered by the dynamic amplification of programmed cell death protein ligand 1(PD-L1) and indoleamine 2, 3-dioxygenase 1(IDO-1) in tumors. To thoroughly liberate PTT efficiency, a bispecific nanomodulator is developed to trigger PTT and dual-block PD-L1 and IDO-1 pathways for boosting effective antitumor immunity. The nanomodulator is excipient-free and self-assembled by leveraging hydrophobic interactions among indocyanine green (ICG), JQ1 and BMS986205 (BMS). The loading efficiency of JQ1 and BMS is as high as 42.0% and 51.8% at a feeding ratio of 1:1. The bispecific nanomodulator efficiently induces PTT and immunogenic cell death (ICD) upon laser irradiation. Moreover, PTT-mediated upregulation of PD-L1 and IDO-1 activation are reversed by the nanomodulator, leading to enhanced infiltration of CD8+ T cells and high levels of TNF-alpha and IFN-gamma in tumors. The bispecific nanomodulator significantly inhibits the growth and metastasis of subcutaneous tumors in mice, and provides defensive effects against tumor rechallenge through immune memory effects. Overall, the bispecific nanomodulator provides a feasible and safe approach for potentiating photothermal immunotherapy against solid tumors.(c) 2022 Elsevier Ltd. All rights reserved.
WOS关键词NANOPARTICLES ; COMBINATION ; THERAPY
资助项目National Natural Science Foundation of China[81903548] ; National Natural Science Foundation of China[32170935] ; National Natural Science Foundation of China[32070927] ; National Natural Science Foundation of China[81690265] ; Strategic Priority Research Program of CAS[XDA12050307] ; Youth Innovation Promotion Association of CAS[2019283] ; Shanghai Sailing Program[19YF1457300]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000783946600002
源URL[http://119.78.100.183/handle/2S10ELR8/299716]  
专题新药研究国家重点实验室
通讯作者Wang, Hao; Wang, Dangge; Li, Yaping
作者单位1.Ecole Polytech Fed Lausanne EPFL, Inst Bioengn, CH-1015 Lausanne, Switzerland
2.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
6.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Lei,Feng, Bing,Wang, Hao,et al. A bispecific nanomodulator to potentiate photothermal cancer immunotherapy[J]. NANO TODAY,2022,44:12.
APA Zhou, Lei,Feng, Bing,Wang, Hao,Wang, Dangge,&Li, Yaping.(2022).A bispecific nanomodulator to potentiate photothermal cancer immunotherapy.NANO TODAY,44,12.
MLA Zhou, Lei,et al."A bispecific nanomodulator to potentiate photothermal cancer immunotherapy".NANO TODAY 44(2022):12.

入库方式： OAI收割

来源：上海药物研究所

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