Quantitative Proteomics Analysis Expands the Roles of Lysine beta-Hydroxybutyrylation Pathway in Response to Environmental beta-Hydroxybutyrate
文献类型：期刊论文
| 作者 | Hou, Wanting2,3; Liu, Guobin3,4; Ren, Xuelian3; Liu, Xianming1; He, Lei1; Huang, He2,3,4,5 |
| 刊名 | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
 |
| 出版日期 | 2022-02-24 |
| 卷号 | 2022页码:15 |
| ISSN号 | 1942-0900 |
| DOI | 10.1155/2022/4592170 |
| 通讯作者 | Huang, He(hhuang@simm.ac.cn) |
| 英文摘要 | Lysine beta-hydroxybutyrylation (Kbhb) is a newly identified protein posttranslational modification (PTM) derived from beta-hydroxybutyrate (BHB), a product of ketone body metabolism in liver. BHB could serve as an energy source and play a role in the suppression of oxidative stress. The plasma concentration of BHB could increase up to 20 mM during starvation and in pathological conditions. Despite the progress, how the cells derived from extrahepatic tissues respond to elevated environmental BHB remains largely unknown. Given that BHB can significantly drive Kbhb, we characterized the BHB-induced lysine beta-hydroxybutyrylome and acetylome by quantitative proteomics. A total of 840 unique Kbhb sites on 429 proteins were identified, with 42 sites on 39 proteins increased by more than 50% in response to BHB. The results showed that the upregulated Kbhb induced by BHB was involved in aminoacyl-tRNA biosynthesis, 2-oxocarboxylic acid metabolism, citrate cycle, glycolysis/gluconeogenesis, and pyruvate metabolism pathways. Moreover, some BHB-induced Kbhb substrates were significantly involved in diseases such as cancer. Taken together, we investigate the dynamics of lysine beta-hydroxybutyrylome and acetylome induced by environmental BHB, which reveals the roles of Kbhb in regulating various biological processes and expands the biological functions of BHB. |
| WOS关键词 | C-MYC PROMOTER ; KETONE-BODIES ; METABOLIC-REGULATION ; PROTEIN COMPLEXES ; FUEL METABOLISM ; GENE-EXPRESSION ; NETWORK |
| 资助项目 | National Natural Science Foundation of China[81973164] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| 出版者 | HINDAWI LTD |
| WOS记录号 | WOS:000777832300002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299719]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, He |
| 作者单位 | 1.Bruker Beijing Sci Technol Co Ltd, Beijing 100192, Peoples R China 2.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Wanting,Liu, Guobin,Ren, Xuelian,et al. Quantitative Proteomics Analysis Expands the Roles of Lysine beta-Hydroxybutyrylation Pathway in Response to Environmental beta-Hydroxybutyrate[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022,2022:15. |
| APA | Hou, Wanting,Liu, Guobin,Ren, Xuelian,Liu, Xianming,He, Lei,&Huang, He.(2022).Quantitative Proteomics Analysis Expands the Roles of Lysine beta-Hydroxybutyrylation Pathway in Response to Environmental beta-Hydroxybutyrate.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022,15. |
| MLA | Hou, Wanting,et al."Quantitative Proteomics Analysis Expands the Roles of Lysine beta-Hydroxybutyrylation Pathway in Response to Environmental beta-Hydroxybutyrate".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022(2022):15. |
入库方式： OAI收割
来源：上海药物研究所
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