Targeted Delivery of Chemotherapeutic Agents for Osteosarcoma Treatment
文献类型：期刊论文
| 作者 | Xie, Duoli2,3,4; Wang, Zhuqian2,3,4; Li, Jie5; Guo, De-an6 ; Lu, Aiping1,3,4,7; Liang, Chao2,3,4
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| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-03-04 |
| 卷号 | 12页码:14 |
| 关键词 | osteosarcoma targeted delivery chemotherapeutic agents ligand-based delivery systems antibodies |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2022.843345 |
| 通讯作者 | Lu, Aiping(aipinglu@hkbu.edu.hk) ; Liang, Chao(liangc@sustech.edu.cn) |
| 英文摘要 | Since osteosarcoma (OS) is an aggressive bone cancer with unknown molecular pathways of etiology and pathophysiology, improving patient survival has long been a challenge. The conventional therapy is a complex multidisciplinary management that include radiotherapy, chemotherapy which followed by surgery and then post-operative adjuvant chemotherapy. However, they have severe side effects because the majority of the medicines used have just a minor selectivity for malignant tissue. As a result, treating tumor cells specifically without damaging healthy tissue is currently a primary goal in OS therapy. The coupling of chemotherapeutic drugs with targeting ligands is a unique therapy method for OS that, by active targeting, can overcome the aforementioned hurdles. This review focuses on advances in ligands and chemotherapeutic agents employed in targeted delivery to improve the capacity of active targeting and provide some insight into future therapeutic research for OS. |
| WOS关键词 | GLEMBATUMUMAB VEDOTIN CDX-011 ; MACROMOLECULAR DRUG-DELIVERY ; LIPID-POLYMER NANOPARTICLES ; SALINOMYCIN DELIVERY ; HYALURONIC-ACID ; CD133 APTAMERS ; IN-VITRO ; FUNCTIONALIZED LIPOSOMES ; BONE METASTASES ; TUMOR |
| 资助项目 | National Natural Science Foundation Council of China[82172386] ; National Natural Science Foundation Council of China[81922081] ; Croucher Foundation[CAS14BU/CAS14201] ; Department of Education of Guangdong Province[2021KTSCX104] ; 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab)[2020B1212030006] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515011450] ; Shenzhen Project of Science and Technology[JCYJ20190809094007719] ; National Natural Science Foundation of China[82104216] ; Science, Technology and Innovation Commission of Shenzhen[JCYJ20210324104201005] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000778354100001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299722]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, Aiping; Liang, Chao |
| 作者单位 | 1.Shanghai Acad Tradit Chinese Med, Inst Arthrit Res Integrat Med, Shanghai, Peoples R China 2.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen, Peoples R China 3.Hong Kong Baptist Univ, Inst Integrated Bioinfomed & Translat Sci IBTS, Sch Chinese Med, Hong Kong, Peoples R China 4.Hong Kong Baptist Univ, Law Sau Fai Inst Adv Translat Med Bone & Joint Di, Sch Chinese Med, Hong Kong, Peoples R China 5.Peking Univ, Shenzhen Hosp, Dept Lab Med, Shenzhen, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab Standardizat Tradit Chinese Med, Shanghai, Peoples R China 7.Guangdong Hong Kong Macau Joint Lab Chinese Med &, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Duoli,Wang, Zhuqian,Li, Jie,et al. Targeted Delivery of Chemotherapeutic Agents for Osteosarcoma Treatment[J]. FRONTIERS IN ONCOLOGY,2022,12:14. |
| APA | Xie, Duoli,Wang, Zhuqian,Li, Jie,Guo, De-an,Lu, Aiping,&Liang, Chao.(2022).Targeted Delivery of Chemotherapeutic Agents for Osteosarcoma Treatment.FRONTIERS IN ONCOLOGY,12,14. |
| MLA | Xie, Duoli,et al."Targeted Delivery of Chemotherapeutic Agents for Osteosarcoma Treatment".FRONTIERS IN ONCOLOGY 12(2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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