Interfering with alternatively activated macrophages by CSF-1R inhibition exerts therapeutic capacity on allergic airway inflammation
文献类型：期刊论文
| 作者 | Xiang, Caigui1,2; Fan, Chen2; Lu, Qiukai1,2; Liu, Moting1,2; Lu, Huimin1,2; Feng, Chunlan2; Wu, Yanwei2; Wu, Bing1,2; Li, Heng2; Tang, Wei1,2
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| 刊名 | BIOCHEMICAL PHARMACOLOGY
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| 出版日期 | 2022-04-01 |
| 卷号 | 198页码:14 |
| 关键词 | Asthma Macrophages CSF-1R Allergy Inflammation |
| ISSN号 | 0006-2952 |
| DOI | 10.1016/j.bcp.2022.114952 |
| 通讯作者 | Li, Heng(cpuliheng@126.com) ; Tang, Wei(tangwei@simm.ac.cn) |
| 英文摘要 | Purpose: Allergic asthma is a chronic inflammatory disorder with airway hyperresponsiveness and tissue remodeling as the main pathological characteristics. The etiology of asthma is relatively complicated, involving genetic susceptibility, epigenetic regulation, environmental factors, and immune imbalance. Colony stimulating factor 1 receptor (CSF-1R), highly expressed in myeloid monocytes, plays an important role in regulating inflammation. However, the pathological role of CSF-1R and the therapeutic effects of CSF-1R inhibitor in allergic airway inflammation remain indistinct.Methods: The house dust mite (HDM)-triggered allergic airway inflammation model was conducted to fully uncover the efficacies of CSF-1R inhibition, as illustrated by histopathological examinations, biochemical analysis, ELISA, RT-PCR, Western blotting assay, immunofluorescence, and flow cytometry. Furthermore, bone marrow-derived macrophages (BMDMs) were differentiated and polarized upon IL-4/IL-13 induction to clarify the underlying mechanisms of CSF-1R inhibition.Results: Herein, we presented that the expression of CSF-1R was increased in HDM-induced experimental asthma and inhibition of CSF-1R displayed dramatic effects on the disease severity of asthma, referring to suppressing the secretion of allergic mediators, dysfunction of airway epithelium, and infiltration of inflammatory cells. Furthermore, CSF-1R inhibitor could markedly restrain the polarization and expression of transcriptional factors of alternatively activated macrophages (AAMs) in the presence of IL-4/IL-13 and reduce the recruitment of CSF1R-dominant macrophages, both in acute and chronic allergic airway inflammation model.Conclusion: Collectively, our findings demonstrated the molecular pathological mechanism of CSF-1R in allergic airway diseases and suggested that targeting CSF-1R might be an alternative intervention strategy on the homeostasis of airway immune microenvironment in asthma. |
| WOS关键词 | EPITHELIAL-CELLS ; ASTHMA ; MECHANISMS ; PATHOPHYSIOLOGY ; EPIDEMIOLOGY ; PEXIDARTINIB ; TUMOR |
| 资助项目 | Science and Technology Commission of Shanghai Municipality[21ZR1474900] ; Science and Technology Commission of Shanghai Municipality[18431907100] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000783146200005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299740]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Heng; Tang, Wei |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Caigui,Fan, Chen,Lu, Qiukai,et al. Interfering with alternatively activated macrophages by CSF-1R inhibition exerts therapeutic capacity on allergic airway inflammation[J]. BIOCHEMICAL PHARMACOLOGY,2022,198:14. |
| APA | Xiang, Caigui.,Fan, Chen.,Lu, Qiukai.,Liu, Moting.,Lu, Huimin.,...&Tang, Wei.(2022).Interfering with alternatively activated macrophages by CSF-1R inhibition exerts therapeutic capacity on allergic airway inflammation.BIOCHEMICAL PHARMACOLOGY,198,14. |
| MLA | Xiang, Caigui,et al."Interfering with alternatively activated macrophages by CSF-1R inhibition exerts therapeutic capacity on allergic airway inflammation".BIOCHEMICAL PHARMACOLOGY 198(2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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