Engineering single-atom catalysts toward biomedical applications
文献类型：期刊论文
| 作者 | Chang, Baisong3; Zhang, Liqin3; Wu, Shaolong3; Sun, Ziyan4; Cheng, Zhen1,2,5,6 |
| 刊名 | CHEMICAL SOCIETY REVIEWS
 |
| 出版日期 | 2022-04-14 |
| 页码 | 47 |
| ISSN号 | 0306-0012 |
| DOI | 10.1039/d1cs00421b |
| 通讯作者 | Chang, Baisong(chang@whut.edu.cn) ; Sun, Ziyan(ziyansun@hust.edu.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Due to inherent structural defects, common nanocatalysts always display limited catalytic activity and selectivity, making it practically difficult for them to replace natural enzymes in a broad scope of biologically important applications. By decreasing the size of the nanocatalysts, their catalytic activity and selectivity will be substantially improved. Guided by this concept, the advances of nanocatalysts now enter an era of atomic-level precise control. Single-atom catalysts (denoted as SACs), characterized by atomically dispersed active sites, strikingly show utmost atomic utilization, precisely located metal centers, unique metal-support interactions and identical coordination environments. Such advantages of SACs drastically boost the specific activity per metal atom, and thus provide great potential for achieving superior catalytic activity and selectivity to functionally mimic or even outperform natural enzymes of interest. Although the size of the catalysts does matter, it is not clear whether the guideline of "the smaller, the better" is still correct for developing catalysts at the single-atom scale. Thus, it is clearly a new, urgent issue to address before further extending SACs into biomedical applications, representing an important branch of nanomedicine. This review begins by providing an overview of recent advances of synthesis strategies of SACs, which serve as a basis for the discussion of emerging achievements in improving the enzyme-like catalytic properties at an atomic level. Then, we carefully compare the structures and functions of catalysts at various scales from nanoparticles, nanoclusters, and few-atom clusters to single atoms. Contrary to conventional wisdom, SACs are not the most catalytically active catalysts in specific reactions, especially those requiring multi-site auxiliary activities. After that, we highlight the unique roles of SACs toward biomedical applications. To appreciate these advances, the challenges and prospects in rapidly growing studies of SACs-related catalytic nanomedicine are also discussed in this review. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; OXYGEN REDUCTION REACTION ; PEROXIDASE-LIKE ACTIVITY ; N-DOPED CARBON ; MIMICKING HORSERADISH-PEROXIDASE ; ION CURRENT RECTIFICATION ; OXIDATIVE STRESS ; COORDINATION-NUMBER ; HYDROGEN-PEROXIDE ; GOLD NANOCLUSTERS |
| 资助项目 | National Natural Science Foundation of China[51803161] ; Natural Science Foundation of Hubei Province, China[2021CFB344] ; Young Top-notch Talent Cultivation Program of Hubei Province, China |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000782973700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299746]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chang, Baisong; Sun, Ziyan; Cheng, Zhen |
| 作者单位 | 1.Stanford Univ, Bio X Program, Stanford, CA 94305 USA 2.Stanford Univ, Dept Radiol, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA 3.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China 5.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Baisong,Zhang, Liqin,Wu, Shaolong,et al. Engineering single-atom catalysts toward biomedical applications[J]. CHEMICAL SOCIETY REVIEWS,2022:47. |
| APA | Chang, Baisong,Zhang, Liqin,Wu, Shaolong,Sun, Ziyan,&Cheng, Zhen.(2022).Engineering single-atom catalysts toward biomedical applications.CHEMICAL SOCIETY REVIEWS,47. |
| MLA | Chang, Baisong,et al."Engineering single-atom catalysts toward biomedical applications".CHEMICAL SOCIETY REVIEWS (2022):47. |
入库方式： OAI收割
来源：上海药物研究所
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