Caulophyine A, a Rare Azapyrene Alkaloid from the Roots of Caulophyllum robustum
文献类型：期刊论文
| 作者 | Wei, Wei1; Yuan, Ya-Hong1; Jiao, Fu-Rong1; Zhao, Xiang2; Xiao, Lei3; Hu, Jia-Yao1; Ji, Ping4; Xiao, Jian1; Wang, Xiao-Ling1 |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2022-04-01 |
| 卷号 | 70期号:4页码:283-285 |
| ISSN号 | 0009-2363 |
| 关键词 | Caulophyllum robustum alkaloid azapyrene |
| 通讯作者 | Xiao, Jian(xjxs163@126.com) ; Wang, Xiao-Ling(xlwangwang@163.com) |
| 英文摘要 | A novel alkaloid caulophyine A (1) was isolated from the roots of Caulophyllum robustum Maxim., along with six known alkaloids 2-7. The structure of 1 was elucidated by extensive NMR and high resolution-time-of-flight (HR-TOF)-MS analyses, it is a rare nitrogen containing polycyclic aromatic hydrocarbon. The in vitro bioassays revealed that 2 presented remarkable cytotoxicity against A549 with an IC50 value of 3.83 mu M in comparison with the positive control etoposide (IC50 =11.63 mu M). Compounds 1 and 2 also displayed weak Acetylcholinesterase (AChE) inhibitory activity with IC50 values of 123.03 and 80.74 mu M respectively. |
| WOS关键词 | ACETYLCHOLINESTERASE ; SAPONINS ; RHIZOMES |
| 资助项目 | National Natural Science Foundation of China[82073727] ; Innovation Capability Support Program of Shaanxi[2018KJXX-044] ; Education Department of Shaanxi Provincial Government[11JS009] ; Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry[17-259-74] ; Science and Technology Program of Baoji[2018JH-08] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| WOS记录号 | WOS:000782151500006 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299752]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xiao, Jian; Wang, Xiao-Ling |
| 作者单位 | 1.Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Shaanxi Key Lab Phytochem, 1 Hitech Ave, Baoji 721013, Shaanxi, Peoples R China 2.Shangluo Vocat & Tech Coll, Publ Course Teaching Dept, Dannan New Area Shangyang Ave, Shangluo 726000, Peoples R China 3.Shaanxi Reg Ctr, Natl Antidrug Lab, Xingxian Rd & Kechuang Rd Cross, Baoji 712000, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Yuan, Ya-Hong,Jiao, Fu-Rong,et al. Caulophyine A, a Rare Azapyrene Alkaloid from the Roots of Caulophyllum robustum[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2022,70(4):283-285. |
| APA | Wei, Wei.,Yuan, Ya-Hong.,Jiao, Fu-Rong.,Zhao, Xiang.,Xiao, Lei.,...&Wang, Xiao-Ling.(2022).Caulophyine A, a Rare Azapyrene Alkaloid from the Roots of Caulophyllum robustum.CHEMICAL & PHARMACEUTICAL BULLETIN,70(4),283-285. |
| MLA | Wei, Wei,et al."Caulophyine A, a Rare Azapyrene Alkaloid from the Roots of Caulophyllum robustum".CHEMICAL & PHARMACEUTICAL BULLETIN 70.4(2022):283-285. |
入库方式： OAI收割
来源：上海药物研究所
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