中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold

文献类型：期刊论文

作者Chen, Weixiong2,3; Feng, Bo4; Han, Sheng3; Wang, Peipei3; Chen, Wuhong3; Zang, Yi3,5; Li, Jia1,3,4,5; Hu, Youhong2,3,5
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2022-02-15
卷号58页码:6
关键词COVID-19 SARS-CoV-2 Main protease inhibitors Benzoisothiazolone
ISSN号0960-894X
DOI10.1016/j.bmcl.2022.128526
通讯作者Zang, Yi(yzang@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn) ; Hu, Youhong(yhhu@simm.ac.cn)
英文摘要The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small molecular compound development. In this work, a series of SARS-CoV-2 main protease (M-pro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 M-pro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 M-pro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.
WOS关键词RNA-POLYMERASE ; SARS ; PROTEASES ; PROTEIN ; COMPLEX
资助项目National Natural Science Foun-dation of China[81872725] ; National Natural Science Foun-dation of China[31871414] ; National Natural Science Foun-dation of China[22107108] ; National Natural Science Foun-dation of China[19430750100] ; Science and Technology Commission of Shanghai Mu-nicipality[18431907100] ; Science and Technology Commission of Shanghai Mu-nicipality[19JC1416300] ; China Postdoctoral Science Foundation[2021M693269]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000783518600003
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/299779]  
专题新药研究国家重点实验室
通讯作者Zang, Yi; Li, Jia; Hu, Youhong
作者单位1.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, 103 Wenhua Rd, Shenyang 110016, Peoples R China
5.UCAS, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Weixiong,Feng, Bo,Han, Sheng,et al. Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2022,58:6.
APA Chen, Weixiong.,Feng, Bo.,Han, Sheng.,Wang, Peipei.,Chen, Wuhong.,...&Hu, Youhong.(2022).Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,58,6.
MLA Chen, Weixiong,et al."Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 58(2022):6.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。