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Construction of the Hexacyclic Core of Dispirocochlearoids A-C via a Diels-Alder Reaction

文献类型：期刊论文

作者Fu, Qiang1,3; Wang, Yonghui1; Nan, Fajun2,3
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2022-04-22
页码5
关键词Natural products Dispirocochlearoids Hexacyclic skeleton Cycloaddition Total synthesis
ISSN号1001-604X
DOI10.1002/cjoc.202200100
通讯作者Wang, Yonghui(yonghuiwang@fudan.edu.cn) ; Nan, Fajun(fjnan@simm.ac.cn)
英文摘要Comprehensive Summary The natural products of dispirocochlearoids are complex Ganoderma meroterpenoids featuring a 6/6/5/6/6/6 ring system and are selective COX-2 inhibitors. Herein, we describe our progress regarding the total synthesis of dispirocochlearoids A-C, in which a hexacyclic skeleton was constructed firstly. The key steps of this work involve an intermolecular [4 + 2] cycloaddition reaction, a ring cleavage approach via TiCl4, and the installation of a profoundly sterically hindering lactone.
WOS关键词POLYCYCLIC MEROTERPENOIDS
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000784802700001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/299791]  
专题新药研究国家重点实验室
通讯作者Wang, Yonghui; Nan, Fajun
作者单位1.Fudan Univ, Sch Pharm, Dept Med Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Shandong, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Qiang,Wang, Yonghui,Nan, Fajun. Construction of the Hexacyclic Core of Dispirocochlearoids A-C via a Diels-Alder Reaction[J]. CHINESE JOURNAL OF CHEMISTRY,2022:5.
APA Fu, Qiang,Wang, Yonghui,&Nan, Fajun.(2022).Construction of the Hexacyclic Core of Dispirocochlearoids A-C via a Diels-Alder Reaction.CHINESE JOURNAL OF CHEMISTRY,5.
MLA Fu, Qiang,et al."Construction of the Hexacyclic Core of Dispirocochlearoids A-C via a Diels-Alder Reaction".CHINESE JOURNAL OF CHEMISTRY (2022):5.

入库方式： OAI收割

来源：上海药物研究所

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