Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial
文献类型：期刊论文
| 作者 | Hai-Na Xie4; Yu-Yuan Chen2,3; Guo-Biao Zhu2,3; Hai-Hao Han2,3; Xi-Le Hu2,3; Zhi-Qiang Pan4; Zang, Yi5 ; Dong-Hao Xie6; Xiao-Peng He2,3; Li, Jia5
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| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2022-04-19 |
| 卷号 | 58期号:32页码:5029-5032 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d1cc06809a |
| 通讯作者 | Hai-Hao Han(hanhaihao@126.com) ; Dong-Hao Xie(xdhdh2012@126.com) ; Li, Jia(jli@simm.ac.cn) ; James, Tony D.(t.d.james@bath.ac.uk) |
| 英文摘要 | A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates, which are then used to coat 2D MoS2. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone. |
| WOS关键词 | HUMAN SERUM-ALBUMIN ; HEPATOCELLULAR-CARCINOMA ; GRAPHENE ; DIAGNOSIS |
| 资助项目 | National Natural Science Foundation of China[22107029] ; National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; Shanghai Science and Technology Committee[19410712600] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; China Postdoctoral Science Foundation[2020M681196] ; Royal Society ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000777730700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299836]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Hai-Hao Han; Dong-Hao Xie; Li, Jia; James, Tony D. |
| 作者单位 | 1.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 2.East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat,Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Materiobiol & D, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Sch Basic Med Sci, 1200 Cailun Rd, Shanghai, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 6.Shanghai Guanghua Hosp Integrat Med, Dept Pharm, 540 Xinghua Rd, Shanghai, Peoples R China 7.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hai-Na Xie,Yu-Yuan Chen,Guo-Biao Zhu,et al. Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial[J]. CHEMICAL COMMUNICATIONS,2022,58(32):5029-5032. |
| APA | Hai-Na Xie.,Yu-Yuan Chen.,Guo-Biao Zhu.,Hai-Hao Han.,Xi-Le Hu.,...&James, Tony D..(2022).Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial.CHEMICAL COMMUNICATIONS,58(32),5029-5032. |
| MLA | Hai-Na Xie,et al."Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial".CHEMICAL COMMUNICATIONS 58.32(2022):5029-5032. |
入库方式： OAI收割
来源：上海药物研究所
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