中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Hydrogen peroxide responsive covalent cyclodextrin framework for targeted therapy of inflammatory bowel disease

文献类型：期刊论文

作者Huang, Chenxi2,3; Xu, Jian2,3; Li, Jing2,3; He, Siyu2,3; Xu, Huipeng2,3; Ren, Xiaohong2; Singh, Vikramjeet1; Wu, Li2,4,5; Zhang, Jiwen2,3,4,5
刊名CARBOHYDRATE POLYMERS
出版日期2022-06-01
卷号285页码:10
关键词Covalent cyclodextrin framework H 2 O 2 responsive Inflammatory bowel disease
ISSN号0144-8617
DOI10.1016/j.carbpol.2022.119252
通讯作者Wu, Li(wuli@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要The incidence and prevalence of inflammatory bowel disease (IBD) are steadily rising worldwide, where the pathogenesis and progression are intrinsically connected to oxidative stress and irregular high levels of reactive oxygen species. To achieve effective therapy for IBD, using hydrogen peroxide (H2O2)-activatable antioxidant prodrug (BRAP) as a linker to crosslink cyclodextrin metal-organic framework, a novel H2O2 responsive covalent cyclodextrin framework (defined as BCOF) was formulated. BCOF featured excellent ROS-responsive hydrolysis and therapeutic p-hydroxybenzyl alcohol released in a H2O2 concentration dependent manner in vitro. Furthermore, BCOF demonstrated 5 times greater retention in the inflamed colon compared to the normal colon in vivo following oral administration. Most importantly, BCOF improved the viability of RAW264.7 cells from H2O2-induced damage in vitro and alleviated the deterioration of IBD with reduced symptoms of inflammation in vivo. In conclusion, our findings suggest that BCOF deserve further consideration as a potential therapeutic nanomedicine for IBD treatment.
WOS关键词METAL-ORGANIC FRAMEWORKS ; P-HYDROXYBENZYL ALCOHOL ; DRUG-DELIVERY SYSTEMS ; ANTIOXIDANT ; NANOPARTICLES ; ENCAPSULATION ; STABILITY
资助项目National Science and Technology Major Projects for National Key R&D Program of China[2020YFE0201700] ; National Science Foundation for Young Scientists of China[81803441] ; National Natural Science Foundation of China[81773645]
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000760998800007
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/299866]  
专题中国科学院上海药物研究所
通讯作者Wu, Li; Zhang, Jiwen
作者单位1.UCL, UCL Mech Engn, Nanoengn Syst Lab, London WC1E 7JE, England
2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Anhui Univ Chinese Med, Anhui Prov Key Lab Pharmaceut Technol & Applicat, Hefei 230012, Peoples R China
5.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Chenxi,Xu, Jian,Li, Jing,et al. Hydrogen peroxide responsive covalent cyclodextrin framework for targeted therapy of inflammatory bowel disease[J]. CARBOHYDRATE POLYMERS,2022,285:10.
APA Huang, Chenxi.,Xu, Jian.,Li, Jing.,He, Siyu.,Xu, Huipeng.,...&Zhang, Jiwen.(2022).Hydrogen peroxide responsive covalent cyclodextrin framework for targeted therapy of inflammatory bowel disease.CARBOHYDRATE POLYMERS,285,10.
MLA Huang, Chenxi,et al."Hydrogen peroxide responsive covalent cyclodextrin framework for targeted therapy of inflammatory bowel disease".CARBOHYDRATE POLYMERS 285(2022):10.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。