Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis
文献类型：期刊论文
| 作者 | Ding, Huihua2,3; Shen, Yiwei2; Lin, Cheng2; Qin, Ling4; He, Shijun3 ; Dai, Min2; Okitsu, Shinji L.5; DeMartino, Julie A.5; Guo, Qiang2; Shen, Nan1,2,6,7
|
| 刊名 | ARTHRITIS RESEARCH & THERAPY
 |
| 出版日期 | 2022-03-28 |
| 卷号 | 24期号:1页码:10 |
| ISSN号 | 1478-6354 |
| 关键词 | Systemic lupus erythematosus Lupus nephritis Galectin-3 binding protein Biomarker Renal biopsy Activity index |
| DOI | 10.1186/s13075-022-02763-4 |
| 通讯作者 | Guo, Qiang(bluedescent@126.com) |
| 英文摘要 | Objective There is an urgent need to identify novel biomarkers of LN to reflect renal histological changes. This study aims to investigate urinary G3BP levels in LN patients and their association with renal disease activity both clinically and pathologically. Methods This is a cross-sectional study. A total of 119 lupus nephritis patients were recruited. Thirty patients with chronic kidney diseases (CKD) and 27 healthy volunteers were also recruited as controls. Urinary G3BP was tested by ELISA. Renal histopathology was reviewed by an experienced renal pathologist. Other clinical variables were collected through chart review. Results The levels of uG3BP were significantly increased in active LN patients compared to those in inactive LN (p<0.001), CKD patients (p=0.01), and healthy controls (p<0.001). ROC analysis indicated a good discrimination ability of uG3BP to differentiate active LN from CKD patients (AUC=0.7), inactive LN (AUC=0.76), or healthy controls (AUC=0.87). uG3BP was positively correlated with SLEDAI (rho=0.352, p<0.001), rSLEDAI (rho=0.302, p<0.001), and SLICC RAS (rho=0.465, p<0.001), indicating a role as a biomarker of disease activity. It also correlated with clinical parameters, including 24-h urine protein, ESR, and serum C3 levels. In patients with 24-h urine protein > 3.0 g/24h, uG3BP levels were higher in proliferative LN than in membranous LN (p=0.04). They could discriminate the two pathogenic types of LN (AUC=0.72), and they also positively correlated with AI (rho=0.389, p=0.008) and scores of hyaline deposits (rho=0.418, p=0.006). While in patients with 24-h urine protein <= 3.0 g/24h, uG3BP levels were not significantly different between proliferative and membranous LN, and there was no apparent relationship between uG3BP levels with AI or with scores of hyaline deposits, but they correlated positively with scores of cellular/fibrocellular crescents (rho=0.328, p=0.04). Conclusion uG3BP is a non-invasive biomarker for clinically and histologically reflecting disease activity. It is associated with active histological changes and can be used as a surrogate biomarker when the renal biopsy is impractical. |
| WOS关键词 | ADHESION MOLECULES ICAM-1 ; E-SELECTIN ; WEGENERS-GRANULOMATOSIS ; INTERNATIONAL SOCIETY ; KIDNEY BIOPSY ; ERYTHEMATOSUS ; VCAM-1 ; EXPRESSION ; VASCULITIS ; REVISION |
| 资助项目 | National Natural Science Foundation of China (NSFC)[82001709] ; State Key Laboratory of Drug Research[SIMM2105KF-06] ; National Natural Science Foundation of China[81771737] ; Shanghai Science and Technology Commission[19411970100] |
| WOS研究方向 | Rheumatology |
| 语种 | 英语 |
| 出版者 | BMC |
| WOS记录号 | WOS:000773925800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299900]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Qiang |
| 作者单位 | 1.Cincinnati Childrens Hosp Med Ctr, Ctr Autoimmune Genom & Etiol, Cincinnati, OH 45229 USA 2.Shanghai Jiao Tong Univ, Sch Med, Dept Rheumatol, Shanghai Inst Rheumatol,Renji Hosp, 145 Shandong M Rd, Shanghai 200001, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 4.Tongji Univ, Shanghai Peoples Hosp 10, Dept Nephrol, Sch Med, Shanghai, Peoples R China 5.EMD Serono, Billerica, MA USA 6.Shanghai Jiao Tong Univ, Renji Hosp, China Australia Ctr Personalized Immunol, Sch Med, Shanghai, Peoples R China 7.Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA |
| 推荐引用方式 GB/T 7714 | Ding, Huihua,Shen, Yiwei,Lin, Cheng,et al. Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis[J]. ARTHRITIS RESEARCH & THERAPY,2022,24(1):10. |
| APA | Ding, Huihua.,Shen, Yiwei.,Lin, Cheng.,Qin, Ling.,He, Shijun.,...&Shen, Nan.(2022).Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis.ARTHRITIS RESEARCH & THERAPY,24(1),10. |
| MLA | Ding, Huihua,et al."Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis".ARTHRITIS RESEARCH & THERAPY 24.1(2022):10. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。