Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis
文献类型：期刊论文
| 作者 | Gao, Yuan1; Du, Ye-Qing1; Zang, Yi1 ; Liu, Hong-Chun1; Wan, Hai-Yan1; Li, Jia1; Li, Xu-Wen1; Guo, Yue-Wei1,2
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| 刊名 | ACS OMEGA
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| 出版日期 | 2022-01-25 |
| 卷号 | 7期号:3页码:3052-3059 |
| ISSN号 | 2470-1343 |
| DOI | 10.1021/acsomega.1c06156 |
| 通讯作者 | Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Twelve new members (1-12) of the dolabellane family, co-occurring with three related known diterpenoids (13-15), were isolated from the Xisha soft coral Clavularia viridis. Their structures were determined by extensive spectroscopic analysis, modified Mosher's method, and X-ray diffraction analysis. Clavuperoxylides A (3) and B (4) represent the first examples of dolabellanes containing peroxyl groups, especially the novel peroxide bridge in 4, whereas clavufuranolides A-C (9-11) are the first example of dolabellane diterpenoids comprising a tetrahydrofuran ring. The possible biogenetic relationship of all the isolates was proposed. In bioassay, several compounds exhibited considerable cytotoxicity against A549 and P388 cell lines. Compound 7 exhibited inhibitory activity against protein tyrosine phosphatases 1B (PTP1B), an anti-diabetic target, representing the first report of PTP1B inhibitory activity for dolabellane diterpenoids. |
| WOS关键词 | MARINE DITERPENOIDS ; SESQUITERPENOIDS |
| 资助项目 | National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[42076099] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000772026100052 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299917]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Du, Ye-Qing,Zang, Yi,et al. Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis[J]. ACS OMEGA,2022,7(3):3052-3059. |
| APA | Gao, Yuan.,Du, Ye-Qing.,Zang, Yi.,Liu, Hong-Chun.,Wan, Hai-Yan.,...&Guo, Yue-Wei.(2022).Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis.ACS OMEGA,7(3),3052-3059. |
| MLA | Gao, Yuan,et al."Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis".ACS OMEGA 7.3(2022):3052-3059. |
入库方式： OAI收割
来源：上海药物研究所
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